Evidence map›Paper›PMID 27587961›Full record

ArticleKorean journal of radiology

Evaluation of the Differences of Myocardial Fibers between Acute and Chronic Myocardial Infarction: Application of Diffusion Tensor Magnetic Resonance Imaging in a Rhesus Monkey Model.

Yuqing Wang, Wei Cai, Lei Wang, Rui Xia, Wei Chen, Jie Zheng, Fabao Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yuqing WangDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Wei CaiDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.; Department of Radiology, Beijing Jishuitan Hospital, 4th Clinical Medical College of Peking University, Beijing 100035, China.
Lei WangDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.
Rui XiaDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.; Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Wei ChenDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.; Department of Radiology, The First Affiliated Hospital of Kunming Medical University, Yunnan 650032, China.
Jie ZhengMallinckrodt Institute of Radiology, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Fabao GaoDepartment of Radiology, West China Hospital, Sichuan University, Sichuan 610041, China.
West China Hospital of Sichuan University · CNSichuan University · CNBeijing Jishuitan Hospital · CNMallinckrodt (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo understand microstructural changes after myocardial infarction (MI), we evaluated myocardial fibers of rhesus monkeys during acute or chronic MI, and identified the differences of myocardial fibers between acute and chronic MI. MATERIALS AND

methodsSix fixed hearts of rhesus monkeys with left anterior descending coronary artery ligation for 1 hour or 84 days were scanned by diffusion tensor magnetic resonance imaging (MRI) to measure apparent diffusion coefficient (ADC), fractional anisotropy (FA) and helix angle (HA).

resultsComparing with acute MI monkeys (FA: 0.59 ± 0.02; ADC: 5.0 ± 0.6 × 10(-4) mm(2)/s; HA: 94.5 ± 4.4°), chronic MI monkeys showed remarkably decreased FA value (0.26 ± 0.03), increased ADC value (7.8 ± 0.8 × 10(-4)mm(2)/s), decreased HA transmural range (49.5 ± 4.6°) and serious defects on endocardium in infarcted regions. The HA in infarcted regions shifted to more components of negative left-handed helix in chronic MI monkeys (-38.3 ± 5.0°-11.2 ± 4.3°) than in acute MI monkeys (-41.4 ± 5.1°-53.1 ± 3.7°), but the HA in remote regions shifted to more components of positive right-handed helix in chronic MI monkeys (-43.8 ± 2.7°-66.5 ± 4.9°) than in acute MI monkeys (-59.5 ± 3.4°-64.9 ± 4.3°).

conclusionDiffusion tensor MRI method helps to quantify differences of mechanical microstructure and water diffusion of myocardial fibers between acute and chronic MI monkey's models.

Indexed as

Acute DiseaseAnimalsAnisotropyChronic DiseaseDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingDisease Models, AnimalFemaleHeartMacaca mulattaMaleMyocardial InfarctionMyocytes, CardiacDiffusion tensor MR imagingDTIHelix angleMyocardial fiberMyocardial infarctionRhesus monkey

Identifiers

PMID27587961
PMCPMC5007399
OpenAlexW2509808624

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.