Evidence map›Paper›PMID 27587941›Full record

ArticlePolymers for advanced technologies2016

Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration.

Joshua R Bush, Haixiang Liang, Molly Dickinson, Edward A Botchwey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers for advanced technologies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A review of advanced hydrogels for cartilage tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
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  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Hemicellulose-based hydrogels for advanced applications.Frontiers in bioengineering and biotechnology · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Joshua R BushDepartment of Orthopaedic Surgery, University of Virginia, PO Box 800374, Charlottesville, VA, 22908, USA.
Haixiang LiangDepartment of Orthopaedic Surgery, University of Virginia, PO Box 800374, Charlottesville, VA, 22908, USA.
Molly DickinsonDepartment of Biomedical Engineering, University of Virginia, PO Box 800359, Charlottesville, VA, 22908, USA.
Edward A BotchweyDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0363, USA.
University of Virginia · USGeorgia Institute of Technology · US

Funding

Phospholipid Growth Factors for Therapeutic Arteriogenesis and Tissue EngineeringR01AR056445 · NIAMS · UNIVERSITY OF VIRGINIA · PI BOTCHWEY, EDWARD A. · 2009 to 2014
$1.8M
Therapeutic S1P Drug Targets for Cranial Bone RepairR01DE019935 · NIDCR · UNIVERSITY OF VIRGINIA · PI BOTCHWEY, EDWARD A. · 2009 to 2013
$1.8M
NIAMS NIH HHS R01 AR056445NIDCR NIH HHS R01 DE019935
6 · The paper itself

Abstract

The hemicellulose xylan, which has immunomodulatory effects, has been combined with chitosan to form a composite hydrogel to improve the healing of bone fractures. This thermally responsive and injectable hydrogel, which is liquid at room temperature and gels at physiological temperature, improves the response of animal host tissue compared with similar pure chitosan hydrogels in tissue engineering models. The composite hydrogel was placed in a subcutaneous model where the composite hydrogel is replaced by host tissue within 1 week, much earlier than chitosan hydrogels. A tibia fracture model in mice showed that the composite encourages major remodeling of the fracture callus in less than 4 weeks. A non-union fracture model in rat femurs was used to demonstrate that the composite hydrogel allows bone regeneration and healing of defects that with no treatment are unhealed after 6 weeks. These results suggest that the xylan/chitosan composite hydrogel is a suitable bone graft substitute able to aid in the repair of large bone defects.

Indexed as

bonehemicellulosehydrogelregenerative medicinexylan

Identifiers

PMID27587941
PMCPMC5004929
OpenAlexW2255435961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.