Evidence map›Paper›PMID 27587902›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2015

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.

Hanna Luhavaya, Marcio V B Dias, Simon R Williams, Hui Hong, Luciana G de Oliveira, Peter F Leadlay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. A Planar Five-Membered Aromatic Ring Stabilized by Only Two π-Electrons.Angewandte Chemie (International ed. in English) · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanna LuhavayaDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (UK).
Marcio V B DiasDepartment of Microbiology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1374, 05508-000, São Paulo-SP (Brazil).
Simon R WilliamsUniversity Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).
Hui HongDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (UK).
Luciana G de OliveiraDepartment of Organic Chemistry, University of Campinas UNICAMP, Cidade Universitária Zeferino Vaz s/n, P.O. Box 6154, 13083-970, Campinas-SP (Brazil).
Peter F LeadlayDepartment of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (UK).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family, but SalBIII plays no role in the conventional cascade of ring opening/closing. Mutation in the

Indexed as

BiosynthesenCyclasenDehydratasenPolyetherPolyketidsynthasen

Identifiers

PMID27587902
PMCPMC4988243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.