Evidence map›Paper›PMID 27587788›Full record

SynthesisCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.

Kristin A Rand, Chi Song, Eric Dean, Daniel J Serie, Karen Curtin, Xin Sheng, Donglei Hu, Carol Ann Huff, Leon Bernal-Mizrachi, Michael H Tomasson and 92 more

Open access · bronzeAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. ArXiv · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Metabolic Disorders in Multiple Myeloma.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Article
  16. Journal of Cancer · 2019
    Article
  17. Review
  18. Article
  19. Genome-Wide Association Studies of Cancer in Diverse Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

102 authors at 3 institutions in 1 country.

Kristin A RandKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Chi SongKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Eric DeanSutter Health, Oakland, California.
Daniel J SerieMayo Clinic, Jacksonville, Florida.
Karen CurtinUniversity of Utah School of Medicine, Salt Lake City, Utah.
Xin ShengKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Donglei HuUniversity of California at San Francisco, San Francisco, California.
Carol Ann HuffJohns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Leon Bernal-MizrachiWinship Cancer Institute, Emory University, Atlanta, Georgia.
Michael H TomassonAlvin J. Siteman Cancer Center, Washington University School of Medicine, Washington University, St. Louis, Missouri.
Sikander AilawadhiMayo Clinic, Jacksonville, Florida.
Seema SinghalRobert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois.
Karen PawlishNew Jersey State Cancer Registry, New Jersey Department of Health, Trenton, New Jersey.
Edward S PetersLouisiana State University School of Public Health, Louisiana State University, New Orleans, Louisiana.
Cathryn H BockKarmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Alex StramGenomic Health, Inc., Redwood City, California.
David J Van Den BergKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Christopher K EdlundKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
David V ContiKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Todd ZimmermanUniversity of Chicago, Chicago, Illinois.
Amie E HwangKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Scott HuntsmanUniversity of California at San Francisco, San Francisco, California.
John GraffRutgers-Robert Wood Johnson Medical School, Rutgers State University of New Jersey, New Brunswick, New Jersey.
Ajay NookaWinship Cancer Institute, Emory University, Atlanta, Georgia.
Yinfei KongKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Silvana L PregjaKarmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, U.S. NIH, Bethesda, Maryland.
William J BlotInternational Epidemiology Institute, Rockville, Maryland.
John CarptenThe Translational Genomics Research Institute, Phoenix, Arizona.
Graham CaseyKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Lisa ChuCancer Prevention Institute of California, Fremont, California.
W Ryan DiverAmerican Cancer Society, Atlanta, Georgia.
Victoria L StevensAmerican Cancer Society, Atlanta, Georgia.
Michael R LieberKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Phyllis J GoodmanSWOG Statistical Center, Seattle, Washington.
Anselm J M HennisStony Brook University, Stony Brook, New York.
Ann W HsingStanford University School of Medicine and Stanford Cancer Institute, Palo Alto, California.
Jayesh MehtaRobert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois.
Rick A KittlesDepartment of Surgery, University of Arizona, Tucson, Arizona.
Suzanne KolbDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Eric A KleinGlickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
Cristina LeskeStony Brook University, Stony Brook, New York.
Adam B MurphyRobert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois.
Barbara NemesureStony Brook University, Stony Brook, New York.
Christine Neslund-DudasHenry Ford Hospital, Detroit, Michigan.
Sara S StromThe University of Texas MD Anderson Cancer Center, University of Texas, Houston, Texas.
Ravi VijAlvin J. Siteman Cancer Center, Washington University School of Medicine, Washington University, St. Louis, Missouri.
Benjamin A RybickiHenry Ford Hospital, Detroit, Michigan.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Lisa B SignorelloHarvard School of Public Health, Harvard University, Boston, Massachusetts.
John S WitteInstitute for Human Genetics, University of California, San Francisco, San Francisco, California.
Christine B AmbrosoneRoswell Park Cancer Institute, Buffalo, New York.
Parveen BhattiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Esther M JohnCancer Prevention Institute of California, Fremont, California.
Leslie BernsteinDivision of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, California.
Wei ZhengInternational Epidemiology Institute, Rockville, Maryland.
Andrew F OlshanGillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.
Jennifer J HuSylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida.
Regina G ZieglerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, U.S. NIH, Bethesda, Maryland.
Sarah J NyanteGillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.
Elisa V BanderaRutgers-Robert Wood Johnson Medical School, Rutgers State University of New Jersey, New Brunswick, New Jersey.
Brenda M BirmannHarvard School of Public Health, Harvard University, Boston, Massachusetts.
Sue A InglesKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Michael F PressKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Djordje AtanackovicUniversity of Utah School of Medicine, Salt Lake City, Utah.
Martha J GlennUniversity of Utah School of Medicine, Salt Lake City, Utah.
Lisa A Cannon-AlbrightUniversity of Utah School of Medicine, Salt Lake City, Utah.
Brandt JonesUniversity of Utah School of Medicine, Salt Lake City, Utah.
Guido TricotUniversity of Iowa, Iowa City, Iowa.
Thomas G MartinUniversity of California at San Francisco, San Francisco, California.
Shaji K KumarMayo Clinic, Rochester, Minnesota.
Jeffrey L WolfUniversity of California at San Francisco, San Francisco, California.
Sandra L Deming HalversonInternational Epidemiology Institute, Rockville, Maryland.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, U.S. NIH, Bethesda, Maryland.
Angela R Brooks-WilsonBC Cancer Agency, Vancouver, Canada.
S Vincent RajkumarMayo Clinic, Rochester, Minnesota.
Laurence N KolonelUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, U.S. NIH, Bethesda, Maryland.
Susan L SlagerMayo Clinic, Rochester, Minnesota.
Richard K SeversonKarmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Nalini JanakiramanHenry Ford Hospital, Detroit, Michigan.
Howard R TerebeloProvidence Hospital, Southfield, Michigan.
Elizabeth E BrownUniversity of Alabama at Birmingham, Birmingham, Alabama.
Anneclaire J De RoosSchool of Public Health, Drexel University, Philadelphia, Pennsylvania.
Ann F MohrbacherKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Graham A ColditzAlvin J. Siteman Cancer Center, Washington University School of Medicine, Washington University, St. Louis, Missouri.
Graham G GilesCancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria, Australia.
John J SpinelliBC Cancer Agency, Vancouver, Canada.
Brian C ChiuUniversity of Chicago, Chicago, Illinois.
Nikhil C MunshiDana Farber Cancer Institute, Harvard School of Medicine, Harvard University, Boston, Massachusetts.
Kenneth C AndersonDana Farber Cancer Institute, Harvard School of Medicine, Harvard University, Boston, Massachusetts.
Joan LevyMultiple Myeloma Research Foundation, Norwalk, Connecticut.
Jeffrey A ZonderKarmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.
Robert Z OrlowskiThe University of Texas MD Anderson Cancer Center, University of Texas, Houston, Texas.
Sagar LonialWinship Cancer Institute, Emory University, Atlanta, Georgia.
Nicola J CampUniversity of Utah School of Medicine, Salt Lake City, Utah.
Celine M VachonMayo Clinic, Rochester, Minnesota.
Elad ZivUniversity of California at San Francisco, San Francisco, California.
Daniel O StramKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Dennis J HazelettCenter for Bioinformatics and Computational Biology, Cedars Sinai Medical Center, Los Angeles, California. wcozen@usc.edu haiman@usc.edu Dennis.Hazelett@csmc.edu.
Christopher A HaimanKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. wcozen@usc.edu haiman@usc.edu Dennis.Hazelett@csmc.edu.
Wendy CozenKeck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. wcozen@usc.edu haiman@usc.edu Dennis.Hazelett@csmc.edu.
University of California, San Francisco · USMayo Clinic in Florida · USNemours Children's Clinic · US

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN CARLISLE CALHOUN · 1992 to 2026
$59.3M
Trageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C., MUNSHI, NIKHIL C. · 2003 to 2023
$45.0M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE, Erica Michelle Stringer-Reasor · 2005 to 2026
$26.6M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Yi Lin · 2015 to 2026
$25.5M
NCCDPHP CDC HHS U58 DP000807NCCDPHP CDC HHS U58 DP003931NCI NIH HHS HHSN261201000026CNCI NIH HHS HHSN261201300021CNCI NIH HHS K05 CA136967NCI NIH HHS K24 CA169004NCI NIH HHS N01 PC035139NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA058223NCI NIH HHS P50 CA100707NCI NIH HHS P50 CA140388NCI NIH HHS P50 CA142509NCI NIH HHS P50 CA186781NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA056678NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA068578NCI NIH HHS R01 CA073629NCI NIH HHS R01 CA082664NCI NIH HHS R01 CA088164NCI NIH HHS R01 CA092579NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA100504NCI NIH HHS R01 CA100598NCI NIH HHS R01 CA134674NCI NIH HHS R01 CA134786NCI NIH HHS R01 CA184464NCI NIH HHS R01 CA186646NCI NIH HHS R01 CA196671NCI NIH HHS R21 CA152336NCI NIH HHS R21 CA155951NCI NIH HHS R21 CA191896NCI NIH HHS R25 CA076023NCI NIH HHS R37 CA054281NCI NIH HHS RC2 CA148085NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA127298NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148065NCI NIH HHS U54 CA118948NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA182883NHGRI NIH HHS U01 HG004726NIEHS NIH HHS P30 ES007784NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES011126NIGMS NIH HHS R35 GM118009
6 · The paper itself

Abstract

backgroundGenome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma.

methodsWe performed association testing of common variation in eight regions in 1,318 patients with multiple myeloma and 1,480 controls of European ancestry and 1,305 patients with multiple myeloma and 7,078 controls of African ancestry and conducted a meta-analysis to localize the signals, with epigenetic annotation used to predict functionality.

resultsWe found that variants in 7p15.3, 17p11.2, 22q13.1 were statistically significantly (P < 0.05) associated with multiple myeloma risk in persons of African ancestry and persons of European ancestry, and the variant in 3p22.1 was associated in European ancestry only. In a combined African ancestry-European ancestry meta-analysis, variation in five regions (2p23.3, 3p22.1, 7p15.3, 17p11.2, 22q13.1) was statistically significantly associated with multiple myeloma risk. In 3p22.1, the correlated variants clustered within the gene body of ULK4 Correlated variants in 7p15.3 clustered around an enhancer at the 3' end of the CDCA7L transcription termination site. A missense variant at 17p11.2 (rs34562254, Pro251Leu, OR, 1.32; P = 2.93 × 10 IMPACT: A subset of reported risk loci for multiple myeloma has consistent effects across populations and is likely to be functional. Cancer Epidemiol Biomarkers Prev; 25(12); 1609-18. ©2016 AACR.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedBlack PeopleFemaleGenetic LociGenome-Wide Association StudyHumansMaleMiddle AgedMultiple MyelomaPolycomb Repressive Complex 1Protein Serine-Threonine KinasesRepressor ProteinsTransmembrane Activator and CAML Interactor ProteinCBX7 protein, humanCDCA7L protein, humanPolycomb Repressive Complex 1Protein Serine-Threonine KinasesRepressor ProteinsTNFRSF13B protein, humanTransmembrane Activator and CAML Interactor ProteinUlk4 protein, human

Identifiers

PMID27587788
PMCPMC5524541
OpenAlexW2508655644

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.