Evidence map›Paper›PMID 27587706›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging.

Suzanne L Baker, Samuel N Lockhart, Julie C Price, Mark He, Ronald H Huesman, Daniel Schonhaut, Jamie Faria, Gil Rabinovici, William J Jagust

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Evaluation of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  2. Parametric methods for [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
  3. Article
  4. Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Regional brain aging patterns reveal disease-specific pathways of neurodegeneration.medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
  9. Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD.The journal of prevention of Alzheimer's disease · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  14. Article
  15. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suzanne L BakerMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, California slbaker@lbl.gov.
Samuel N LockhartHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California.
Julie C PriceDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania; and.
Mark HeHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California.
Ronald H HuesmanMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, California.
Daniel SchonhautMemory and Aging Center, University of California San Francisco, San Francisco, California.
Jamie FariaMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, California.
Gil RabinoviciMemory and Aging Center, University of California San Francisco, San Francisco, California.
William J JagustMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, California.

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Early Age-of-Onset AD: Clinical Heterogeneity and Network DegenerationR01AG045611 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RABINOVICI, GIL DAN · 2014 to 2018
$3.1M
NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG045611
6 · The paper itself

Abstract

The goal of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET radioligand

methods

resultsSRTM2 BP

conclusionDespite later time periods providing better agreement between reference standards and SUVRs for hROIs, a good compromise for studying lROIs and hROIs is SUVR80-100. The lack of SUVR plateau for hROIs highlights the importance of precise acquisition time for longitudinal assessment.

Indexed as

AgedAlzheimer DiseaseBiomarkersBrainCarbolinesComputer SimulationFemaleHumansImage EnhancementKineticsMaleMetabolic Clearance RateMiddle AgedModels, BiologicalMolecular ImagingPositron-Emission Tomography7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleBiomarkersCarbolinesRadiopharmaceuticalstau Proteins18F-AV-1451Alzheimer’skineticstau

Identifiers

PMID27587706
PMCPMC5288744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.