Evidence map›Paper›PMID 27587472›Full record

SynthesisJournal of medical genetics2016

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

Iris Postmus, Helen R Warren, Stella Trompet, Benoit J Arsenault, Christy L Avery, Joshua C Bis, Daniel I Chasman, Catherine E de Keyser, Harshal A Deshmukh, Daniel S Evans and 78 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  10. Association ofPharmacogenomics and personalized medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

88 authors at 20 institutions in 9 countries.

Iris PostmusDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Helen R WarrenDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Stella TrompetDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Benoit J ArsenaultMontreal Heart Institute, Université de Montréal, Montreal, Canada.
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Catherine E de KeyserDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Harshal A DeshmukhMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
QiPing FengDepartment of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Pediatrics and Medicine at Harbor-UCLA Medical Center, Torrance, California, USA.
Roelof A J SmitDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Fangui SunDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Pediatrics and Medicine at Harbor-UCLA Medical Center, Torrance, California, USA.
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Michael R BarnesDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Bryan J BarrattPersonalised Healthcare and Biomarkers AstraZeneca Research and Development, Alderley Park, UK.
John BetteridgeUniversity College London Hospital, London, UK.
S Matthijs BoekholdtDepartment of Cardiology, Academic Medical Center, Amsterdam, North Holland, Netherlands.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Western Road, Cork, Ireland.
Y-D Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Pediatrics and Medicine at Harbor-UCLA Medical Center, Torrance, California, USA.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA.
Marie Pierre DubéMontreal Heart Institute, Université de Montréal, Montreal, Canada.
Paul N DurringtonCardiovascular Research Group, School of Biosciences, University of Manchester, Manchester, UK.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Pediatrics and Medicine at Harbor-UCLA Medical Center, Torrance, California, USA.
Tamara B HarrisLaboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, North Holland, Netherlands.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, North Holland, Netherlands.
Leonore J LaunerLaboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Thomas LumleyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Paul M McKeigueCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Patricia B MunroeDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Andrew NeilOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Fredrik NybergMedical Evidence and Observational Research, AstraZeneca Gothenburg, Mölndal, Sweden.
Eoin O'BrienThe Conway Institute, University College Dublin, Dublin 4, Ireland.
Christopher J O'DonnellFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Wendy PostDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, London, UK.
Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, and the Framingham Heart Study, Framingham, Massachusetts, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Naveed SattarInstitute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, Scotland.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Sue Shaw-HawkinsDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Denis C ShieldsThe Conway Institute, University College Dublin, Dublin 4, Ireland.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Joshua D SmithDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Alice StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
David J StottFaculty of Medicine, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Til StürmerDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA.
Rudi G J WestendorpDepartment of Public Health, Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark.
Eric A WhitselDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2749-1279
Russell A WilkeDepartment of Internal Medicine, Sanford Healthcare, Sioux Falls, South Dakota, USA.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Helen M ColhounMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Graham HitmanBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jeanette M StaffordDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Charles M SteinDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, Montreal, Canada.
Mark J CaulfieldDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Pediatrics and Medicine at Harbor-UCLA Medical Center, Torrance, California, USA.
Ronald M KraussDepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
University of Washington · USLeiden University Medical Center · NLQueen Mary University of London · GBErasmus MC · NLThe Lundquist Institute · USBoston University · USVanderbilt University · USAmsterdam UMC Location University of Amsterdam · NLGroup Health Cooperative · USMontreal Heart Institute · CAUniversity of Dundee · GBUniversity of Glasgow · GBUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USCalifornia Pacific Medical Center · USImperial College London · GBNational Institutes of Health · USUniversity College Dublin · IEUniversity of Iceland · ISWake Forest University · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
Pharmacogenomics and Risk of Cardiovascular DiseaseU19HL069757 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI KRAUSS, RONALD M · 2010 to 2014
$12.8M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Department of HealthIntramural NIH HHS Z01 AG007380Medical Research Council G0600237Medical Research Council MR/K006584/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004603NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL043201NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U19 HL069757NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS U24 AG051129NICHD NIH HHS P2C HD050924NIDDK NIH HHS P30 DK063491NIGMS NIH HHS P50 GM115305Wellcome TrustWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

backgroundIn addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND

resultsWe performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10

conclusionsBased on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.

Indexed as

Pharmacogenomic VariantsPolymorphism, Single NucleotideCholesterol Ester Transfer ProteinsCholesterol, HDLFemaleGenome-Wide Association StudyHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleTreatment OutcomeWhite PeopleCETP protein, humanCholesterol Ester Transfer ProteinsCholesterol, HDLHydroxymethylglutaryl-CoA Reductase InhibitorsGenome-wide association studyHDL-cholesterolpharmacogeneticsStatins

Identifiers

PMID27587472
PMCPMC5309131
OpenAlexW2508142392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.