Evidence map›Paper›PMID 27587420›Full record

ArticleAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2016

Sequential Organ Failure Assessment Score Modified for Recent Infection in Patients With Hematologic Malignant Tumors and Severe Sepsis.

Jared A Greenberg, Michael Z David, Matthew M Churpek, David L Pitrak, Jesse B Hall, John P Kress

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In one paragraph

Article in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jared A GreenbergJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago. Jared_greenberg@rush.edu.
Michael Z DavidJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago.
Matthew M ChurpekJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago.
David L PitrakJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago.
Jesse B HallJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago.
John P KressJared A. Greenberg is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois. Matthew M. Churpek is an assistant professor, Jesse B. Hall is a professor, and John P. Kress is a professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois. Michael Z. David is an assistant professor and David L. Pitrak is a professor, Section of Infectious Disease and Global Health, Department of Medicine, University of Chicago.

Funding

RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M
Predicting In-hospital Cardiac Arrest Using Electronic Health Record DataK08HL121080 · NHLBI · UNIVERSITY OF CHICAGO · PI CHURPEK, MATTHEW MICHAEL · 2014 to 2018
$751k
NHLBI NIH HHS K08 HL121080NHLBI NIH HHS T32 HL007605
6 · The paper itself

Abstract

backgroundBaseline health status influences outcomes of severe sepsis.

objectiveTo determine if recent infection is a marker of poor health in patients with hematologic malignant tumors and severe sepsis by modifying the Sequential Organ Failure Assessment (SOFA) score to account for infection.

methodsMedical records of the first 50 patients with hematologic malignant tumors and severe sepsis admitted from September 1, 2009 to September 1, 2014, were reviewed to derive a modified SOFA score. The predictive accuracy of the modified score was compared with that of the unmodified score and the Acute Physiology and Chronic Health Evaluation (APACHE) II score for the 196 subsequent patients.

resultsThe area under the receiver operator characteristic curve was 0.73 (95% CI, 0.66-0.80) for the modified score, 0.68 (95% CI, 0.61-0.76) for the unmodified score, and 0.65 (95% CI, 0.58-0.73) for the APACHE II score. The modified score was better for discriminating survivors from nonsurvivors than the unmodified score (P = .005) and the APACHE II score (P = .04). After adjustments for the modified score and age, only increased days from hospital to intensive care unit admission was significantly associated with 30-day mortality.

conclusionModifying the SOFA score to account for infections before admission to the intensive care unit improved the prognostic usefulness of the scores for patients with hematologic malignant tumors and severe sepsis.

Indexed as

Organ Dysfunction ScoresAgedAge FactorsAPACHEFemaleHematologic NeoplasmsHumansIntensive Care UnitsLength of StayMaleMiddle AgedPrognosisRetrospective StudiesROC CurveSepsisSeverity of Illness Index

Identifiers

PMID27587420
PMCPMC5119527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.