Evidence map›Paper›PMID 27587383›Full record

ArticleHaematologica2016

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.

Lianne E Rotin, Neil MacLean, Ahmed Aman, Marcela Gronda, Feng-Hsu Lin, Rose Hurren, XiaoMing Wang, Jeffrey L Wrana, Alessandro Datti, Rima Al-Awar and 2 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Lianne E RotinPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Neil MacLeanPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Ahmed AmanDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Marcela GrondaPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Feng-Hsu LinPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Rose HurrenPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
XiaoMing WangPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Jeffrey L WranaSamuel Lunenfeld Research Institute, Toronto, ON, Canada.
Alessandro DattiSamuel Lunenfeld Research Institute, Toronto, ON, Canada.
Rima Al-AwarDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Mark D MindenPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
Aaron D SchimmerPrincess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada aaron.schimmer@utoronto.ca.
Princess Margaret Cancer Centre · CAUniversity Health Network · CAUniversity of Toronto · CALunenfeld-Tanenbaum Research Institute · CAOntario Institute for Cancer Research · CAUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Line, TumorDrug SynergismErlotinib HydrochlorideEthacridineGlycoside HydrolasesHumansLeukemia, Myeloid, AcuteErlotinib HydrochlorideEthacridineGlycoside Hydrolasespoly ADP-ribose glycohydrolase

Identifiers

PMID27587383
PMCPMC5394872
OpenAlexW2514747241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.