Evidence map›Paper›PMID 27586847›Full record

ReviewReviews in endocrine & metabolic disorders2017

Gonadal dysfunction in chronic kidney disease.

Biff F Palmer, Deborah J Clegg

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04710238 (Assessment of Gonadal Functions in Hemodialysis Male Patients on Regular Hemodialysis), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710238 unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Gonadal Functions in Hemodialysis Male Patients on Regular Hemodialysis :A Cross-Sectional Study.

Typeobservational_patient_registrySponsorAssiut UniversityRan2021 to 2022Enrolled100ConditionsESRD
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Effects of valganciclovir on spermatogenesis in renal transplant patients - results of a multicenter prospective nonrandomized study.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Trial
  3. Article
  4. Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Pregnancy and its outcomes in hemodialysis patients in Turkey.Turkish journal of medical sciences · 2022
    Article
  16. Pregnancy and its outcomes in hemodialysis patients in Turkey.Turkish journal of medical sciences · 2021
    Article
  17. Article
  18. Use of Sertraline in Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Biff F PalmerDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. biff.palmer@utsouthwestern.edu.
Deborah J CleggBiomedical Research Department, Diabetes and Obesity Research Division, Cedars-Sinai Medical Center, California, LA, USA.
Cedars-Sinai Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sexual dysfunction is a common finding in both men and women with chronic kidney failure. Common disturbances include erectile dysfunction in men, menstrual abnormalities in women, and decreased libido and fertility in both sexes. These abnormalities are primarily organic in nature and are related to uremia as well as the other comorbid conditions that frequently occur in the chronic kidney failure patient. Fatigue and psycho social factors related to the presence of a chronic disease are also contributory factors. Disturbances in the hypothalamic-pituitary-gonadal axis can be detected prior to the need for dialysis but continue to worsen once dialytic therapy is initiated. Impaired gonadal function is prominent in uremic men while the disturbances in the hypothalamic-pituitary axis are more subtle. By contrast, central disturbances are more prominent in uremic women. Therapy is initially directed towards optimizing the delivery of dialysis, correcting anemia with recombinant erythropoietin, and controlling the degree of secondary hyperparathyroidism with vitamin D. For many practicing nephrologists sildenafil has become the first line therapy in the treatment of impotence. In the hypogonadal man whose only complaint is decreased libido, testosterone may be of benefit. Regular gynecologic follow up is required in uremic women to guard against potential complications of unopposed estrogen effect. Uremic women should be advised against pregnancy while on dialysis. Successful transplantation is the most effective means of restoring normal sexual function in both men and women with chronic kidney failure.

Indexed as

FemaleHumansMaleRenal Insufficiency, ChronicSexual Dysfunction, PhysiologicalUremiaAmennorheaAnovulationDialysisErectile dysfunctionEstrogenGonadotropin deficiencyImpotencePituitary-gonadal axisSildenafilTestosteroneTransplantation erectile dysfunctionUremia

Identifiers

PMID27586847
OpenAlexW2510732814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.