Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2017
The impact of postexercise essential amino acid ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Exercise Mitigates the Loss of Muscle Mass by Attenuating the Activation of Autophagy during Severe Energy Deficit.Nutrients · 2019Trial
- Is there a volume saturation point for muscle hypertrophy in resistance-trained individuals? A narrative review.European journal of applied physiology · 2025Review
- Recycle, repair, recover: the role of autophagy in modulating skeletal muscle repair and post-exercise recovery.Bioscience reports · 2025Review
- Aging and Autophagy: Roles in Musculoskeletal System Injury.Aging and disease · 2024Review
- Review
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- Impact of essential amino acid intake, resistance exercise, and aging on the concentration of Achilles peritendinous amino acids and procollagen Iα1 in humans.Amino acids · 2023Article
- The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle.European journal of applied physiology · 2021Article
- Low-Grade Systemic Inflammation Interferes with Anabolic and Catabolic Characteristics of the Aged Human Skeletal Muscle.Oxidative medicine and cellular longevity · 2021Article
- More than just a garbage can: emerging roles of the lysosome as an anabolic organelle in skeletal muscle.American journal of physiology. Cell physiology · 2020Review
- Long-Term Recreational Football Training and Health in Aging.International journal of environmental research and public health · 2020Review
- Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion.Frontiers in physiology · 2019Article
- Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans.Sports medicine (Auckland, N.Z.) · 2018Review
- Recent advances in pharmacological, hormonal, and nutritional intervention for sarcopenia.Pflugers Archiv : European journal of physiology · 2018Review
- Autophagy-Dependent Beneficial Effects of Exercise.Cold Spring Harbor perspectives in medicine · 2017Review
- Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.Oxidative medicine and cellular longevity · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Essential amino acid (EAA) ingestion enhances postexercise muscle protein synthesis, and, in particular, the anabolic response of older adults appears sensitive to the quantity of ingested leucine. The effect of leucine ingestion on muscle breakdown following resistance exercise (RE) is less understood. The purpose of this study was to identify the impact of postexercise leucine ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems following acute RE in older men. Subjects (72 ± 2 yr) performed RE and 1 h postexercise ingested 10 g of EAA containing a leucine quantity similar to quality protein (control, 1.8 g leucine,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.