Evidence map›Paper›PMID 27586835›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016

A structure-function analysis of the left ventricle.

Edward P Snelling, Roger S Seymour, J E F Green, Leith C R Meyer, Andrea Fuller, Anna Haw, Duncan Mitchell, Anthony P Farrell, Mary-Ann Costello, Adian Izwan and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Edward P SnellingBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa; edward.snelling@wits.ac.za.ORCID 0000-0002-8985-8737
Roger S SeymourSchool of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-3395-0059
J E F GreenSchool of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-5061-9563
Leith C R MeyerBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa; Department of Paraclinical Sciences, University of Pretoria, Pretoria, South Africa.
Andrea FullerBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa; Department of Paraclinical Sciences, University of Pretoria, Pretoria, South Africa.
Anna HawBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
Duncan MitchellBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa; School of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, Western Australia, Australia.
Anthony P FarrellDepartment of Zoology, University of British Columbia, Vancouver, British Columbia, Canada; Faculty of Land and Food Systems, University of British Columbia, Vancouver, British Columbia, Canada.
Mary-Ann CostelloCentral Animal Service, University of the Witwatersrand, Johannesburg, South Africa; and.
Adian IzwanSchool of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, Western Australia, Australia.
Margaret BadenhorstSchool of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
Shane K MaloneyBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa; School of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, Western Australia, Australia.
University of the Witwatersrand · ZAThe University of Western Australia · AUThe University of Adelaide · AUUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a structure-function analysis of the mammalian left ventricle and examines the performance of the cardiac capillary network, mitochondria, and myofibrils at rest and during simulated heavy exercise. Left ventricular external mechanical work rate was calculated from cardiac output and systemic mean arterial blood pressure in resting sheep (Ovis aries; n = 4) and goats (Capra hircus; n = 4) under mild sedation, followed by perfusion-fixation of the left ventricle and quantification of the cardiac capillary-tissue geometry and cardiomyocyte ultrastructure. The investigation was then extended to heavy exercise by increasing cardiac work according to published hemodynamics of sheep and goats performing sustained treadmill exercise. Left ventricular work rate averaged 0.017 W/cm

Indexed as

Models, CardiovascularAnimalsBlood PressureCardiac OutputComputer SimulationFemaleGoatsHeart VentriclesMaleMitochondria, HeartModels, AnatomicOrgan SizeOxygenOxygen ConsumptionSheepVentricular Function, LeftOxygencapillaryheartmitochondriamyofibrilwork

Identifiers

PMID27586835
PMCPMC5142313
OpenAlexW2509571534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.