ReviewThe journal of pain2016
Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.
Review in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 288 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double Blind, Placebo-Controlled Single Center Phase 2 Pilot Study to Assess the Safety and Efficacy of Off-label Subcutaneous Administration of Erenumab-aooe in Patients With Temporomandibular Disorder
Disrupted Spatial and Temporal Nociceptive Filtering in Adolescents With and Risk for Overlapping Pain Conditions
Pain Outcomes Associated With Exogenous Hormone Therapy in Adults
Comparing the Effectiveness of Online vs. One-on-one vs. Group Physiotherapy for Treating Myogenic Temporomandibular Disorders: A Randomized Controlled Trial
Who cites it
288 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative transcriptomic meta-analysis reveals elevated TCL1A expression in human circulating immune cells across chronic pain conditions.British journal of anaesthesia · 2026Pooled it
- The Interplay Between Chronic Pelvic Pain and Pelvic Organ Prolapse.International urogynecology journal · 2025Pooled it
- Temporomandibular Disorders and Fibromyalgia Prevalence: A Systematic Review and Meta-Analysis.Journal of oral & facial pain and headache · 2023Pooled it
- Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial.Annals of medicine · 2026Trial
- Trial
- Pain relief by targeting nonrestorative sleep in fibromyalgia: a phase 3 randomized trial of bedtime sublingual cyclobenzaprine.Pain medicine (Malden, Mass.) · 2026Trial
- A randomized, double blind, placebo-controlled pilot study to assess the efficacy of erenumab in individuals with temporomandibular disorder.Journal of oral & facial pain and headache · 2025Trial
- Importance of pain perception after mucogingival surgery in multiple Miller class III/RT2 gingival recessions: A randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2025Trial
- Trial
- A Primary Care-Based Cognitive Behavioral Therapy Intervention for Long-Term Opioid Users With Chronic Pain : A Randomized Pragmatic Trial.Annals of internal medicine · 2022Trial
- Chronic pelvic and related genital pain in transgender and gender-diverse people: a scoping review.EClinicalMedicine · 2026Review
- Mixed pain phenotypes in musculoskeletal disorders: mechanisms and management.Nature reviews. Rheumatology · 2026Review
- Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.Pain and therapy · 2026Review
- Comorbidities in Patients with Acute and Chronic Temporomandibular Disorders: An Exploratory Retrospective Study with a Conceptual Interdisciplinary Assessment Framework.Healthcare (Basel, Switzerland) · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Biobehavioral pain profiling of minoritized adults with chronic widespread pain and clinical obesity before and after bariatric surgery: study protocol for a longitudinal, observational cohort study.medRxiv : the preprint server for health sciences · 2026Article
- Chronic Ocular Surface Pain: A Missing Member of the Chronic Overlapping Pain Conditions?Drugs · 2026Review
- Exploring the role of chronic overlapping pain conditions on smoking dependence, cessation challenges, and internalizing psychopathology among individuals with irritable bowel syndrome who smoke.Journal of behavioral medicine · 2026Article
- Integrating the Central Sensitization Inventory (CSI) into Neuropelveological Practice: A Systematic Review of Endometriosis and Overlapping Pelvic Pain Syndromes.Journal of clinical medicine · 2026Review
- Differential Characteristics, Mechanisms, and Clinical Strategies for Perioperative Dry Eye in Presenile Cataract and Age-Related Cataract.Healthcare (Basel, Switzerland) · 2026Review
228 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
unlabelledThere is increasing recognition that many if not most common chronic pain conditions are heterogeneous with a high degree of overlap or coprevalence of other common pain conditions along with influences from biopsychosocial factors. At present, very little attention is given to the high degree of overlap of many common pain conditions when recruiting for clinical trials. As such, many if not most patients enrolled into clinical studies are not representative of most chronic pain patients. The failure to account for the heterogeneous and overlapping nature of most common pain conditions may result in treatment responses of small effect size when these treatments are administered to patients with chronic overlapping pain conditions (COPCs) represented in the general population. In this brief review we describe the concept of COPCs and the putative mechanisms underlying COPCs. Finally, we present a series of recommendations that will advance our understanding of COPCs. PERSPECTIVE: This brief review describes the concept of COPCs. A mechanism-based heuristic model is presented and current knowledge and evidence for COPCs are presented. Finally, a set of recommendations is provided to advance our understanding of COPCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.