Evidence map›Paper›PMID 27586499›Full record

ReviewPituitary2017

Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary.

Luis V Syro, Fabio Rotondo, Carlos A Serna, Leon D Ortiz, Kalman Kovacs

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Clinicopathological Spectrum of Acromegaly.Journal of clinical medicine · 2019
    Review
  9. Pituitary Pathology and Gene Expression in Acromegalic Cats.Journal of the Endocrine Society · 2019
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Luis V SyroDepartment of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia. lvsyro@une.net.co.
Fabio RotondoDepartment of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Carlos A SernaLaboratorio de Patologia y Citologia Rodrigo Restrepo. Department of Pathology, Clinica Las Americas, Universidad CES, Medellin, Colombia.
Leon D OrtizDivision of Neuro-oncology, Instituto de Cancerologia, Clinica Las Americas, Medellin, Colombia.
Kalman KovacsDepartment of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Clínica CES · COHospital Pablo Tobon Uribe · COInstituto de Cancerología Las Américas · COSt. Michael's Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHistologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH-releasing hormone secreting tumors or in familial pituitary tumor syndromes. MATERIALS AND

methodsA literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.

resultsThis review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.

conclusionThe importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.

Indexed as

AcromegalyFemaleGrowth HormoneHumansHyperplasiaMalePituitary GlandPituitary NeoplasmsGrowth HormoneAcromegalyClassificationDiagnosisImmunohistochemistryPathologyPituitary neoplasms

Identifiers

PMID27586499
OpenAlexW2516616785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.