ArticleJournal of neurology2016
Mortality trends of amyotrophic lateral sclerosis in Norway 1951-2014: an age-period-cohort study.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Mortality From Amyotrophic Lateral Sclerosis in Finland 1987-2022.European journal of neurology · 2026Article
- Motor Neuron Disease Mortality Trends in Australia From 1986 to 2023: A Population-Based Study.The Medical journal of Australia · 2026Article
- Disease trajectories and end of life care in a Norwegian ALS cohort.BMC neurology · 2026Article
- Age-period-cohort effect on motor neuron disease mortality in the United States, 2001-2020.Frontiers in neurology · 2025Article
- Tuberculin responses after BCG vaccination predict amyotrophic lateral sclerosis risk.Brain, behavior, & immunity - health · 2023Article
- Article
- Geographic Analysis of Motor Neuron Disease Mortality and Heavy Metals Released to Rivers in Spain.International journal of environmental research and public health · 2018Article
- Alterations in the stomatognathic system due to amyotrophic lateral sclerosis.Journal of applied oral science : revista FOB · 2018Article
- Sex ratio in multiple sclerosis mortality over 65 years; an age-period-cohort analysis in Norway.Journal of neurology · 2018Article
- Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register.JAMA neurology · 2017Article
- Gene discovery in amyotrophic lateral sclerosis: implications for clinical management.Nature reviews. Neurology · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest that the incidence and mortality of amyotrophic lateral sclerosis (ALS) are increasing. Changing environmental factors could influence disease risk differently throughout life span, and also between genders, birth cohorts, and seasons of birth. We aimed at describing long-term ALS mortality trends in Norway between 1951 and 2014 using age-period-cohort analysis. The Norwegian Cause of Death Registry provided ALS mortality data that were age- and sex-adjusted through direct standardization. Poisson regression analyses were used for identification of mortality trends and potential month of birth effects. We identified 5345 ALS cases, of which 54.7 % were men. ALS mortality increased throughout the whole period (p < 0.001), with a mean annual increase of 1.14 %. The increase was confined to those older than 60 years, but rates consistently dropped amongst the absolute oldest. The increase was mainly driven by birth cohort effects that increased from 1860 until 1934 (p < 0.001). No month of birth effect or change in sex ratio was found. The continuous increase in ALS mortality since 1951 is best explained by the long-term changes in exposure to risk factors or in case ascertainment, affecting men and women equally in the generations born since 1860 and at least into 1934.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.