ArticleIn vitro cellular & developmental biology. Animal2017
Fat body and hemocyte contribution to the antimicrobial peptide synthesis in Calliphora vicina R.-D. (Diptera: Calliphoridae) larvae.
Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Crosstalk BetweenInsects · 2026Article
- Genome-wide identification and immunological expression analysis of the C3HC4-type zinc finger protein genes in the silkworm, Bombyx Mori.BMC genomics · 2026Article
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- Human Defensin 5 InhibitsTropical medicine and infectious disease · 2024Article
- Mechanisms and roles of the first stage of nodule formation in lepidopteran insects.Journal of insect science (Online) · 2023Article
- Establishing and characterising a new cell line fromHeliyon · 2022Article
- Mass Spectrometry-Based Peptide Profiling of Haemolymph fromMolecules (Basel, Switzerland) · 2022Article
- Review
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- Insights Into the Immune Response of the Black Soldier Fly Larvae to Bacteria.Frontiers in immunology · 2021Article
- Characterising four Sarconesiopsis magellanica (Diptera: Calliphoridae) larval fat body-derived antimicrobial peptides.Memorias do Instituto Oswaldo Cruz · 2021Article
- Transcriptome and microbiome of coconut rhinoceros beetle (Oryctes rhinoceros) larvae.BMC genomics · 2019Article
- Hemocyte-hemocyte adhesion by granulocytes is associated with cellular immunity in the cricket, Gryllus bimaculatus.Scientific reports · 2019Article
- Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours inDisease models & mechanisms · 2019Article
- Sarconesin II, a New Antimicrobial Peptide Isolated fromMolecules (Basel, Switzerland) · 2019Article
- Sarconesin:Frontiers in microbiology · 2018Article
- Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots.PloS one · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides accumulated in the hemolymph in response to infection are a key element of insect innate immunity. The involvement of the fat body and hemocytes in the antimicrobial peptide synthesis is widely acknowledged, although release of the peptides present in the hemolymph from the immune cells was not directly verified so far. Here, we studied the presence of antimicrobial peptides in the culture medium of fat body cells and hemocytes isolated from the blue blowfly Calliphora vicina using complex of liquid chromatography, mass spectrometry, and antimicrobial activity assays. Both fat body and hemocytes are shown to synthesize and release to culture medium defensin, cecropin, diptericins, and proline-rich peptides. The spectra of peptide antibiotics released by the fat body and hemocytes partially overlap. Thus, the results suggest that insect fat body and blood cells are capable of releasing mature antimicrobial peptides to the hemolymph. It is notable that the data obtained demonstrate dramatic difference in the functioning of insect antimicrobial peptides and their mammalian counterparts localized into blood cells' phagosomes where they exert their antibacterial activity.
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