ArticleJournal of agricultural and food chemistry2016
Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.
Article in Journal of agricultural and food chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
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- Dehydrodiisoeugenol targets NOD2 exerting dual effects against colitis and colorectal cancer: a double-edged sword.Molecular medicine (Cambridge, Mass.) · 2025Article
- TRPV1: The key bridge in neuroimmune interactions.Journal of intensive medicine · 2024Review
- Phytochemical Composition and Biological Activity of the Essential Oil fromPlants (Basel, Switzerland) · 2024Article
- Comprehensive analysis ofFood science & nutrition · 2024Article
- The "root" causes behind the anti-inflammatory actions of ginger compounds in immune cells.Frontiers in immunology · 2024Review
- Triphenylphosphine Derivatives of Allylbenzenes Express Antitumor and Adjuvant Activity When Solubilized with Cyclodextrin-Based Formulations.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Volatile Composition, Antimicrobial Activity, and In Vitro Innate Immunomodulatory Activity ofMolecules (Basel, Switzerland) · 2023Article
- Essential Oil ofMolecules (Basel, Switzerland) · 2023Article
- How to Naturally Support the Immune System in Inflammation-Essential Oils as Immune Boosters.Biomedicines · 2023Review
- Composition and Biological Activity of the Essential Oils from Wild Horsemint, Yarrow, and Yampah from Subalpine Meadows in Southwestern Montana: Immunomodulatory Activity of Dillapiole.Plants (Basel, Switzerland) · 2023Article
- Improving the Stability and Effectiveness of Immunotropic Squalene Nanoemulsion by Adding Turpentine Oil.Biomolecules · 2023Article
- Blend of essential oils can reduce diarrheal disorders and improve liver antioxidant status in weaning piglets.Animal bioscience · 2023Article
- Enhancement of neutrophil chemotaxis by trans-anethole-treated Staphylococcus aureus strains.PloS one · 2023Article
- Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils fromPlants (Basel, Switzerland) · 2022Article
- Neutrophil Immunomodulatory Activity of (-)-Borneol, a Major Component of Essential Oils Extracted fromMolecules (Basel, Switzerland) · 2022Article
- Neutrophil Immunomodulatory Activity of Farnesene, a Component ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Synthesis and Antiproliferative Activity of Triphenylphosphonium Derivatives of Natural Allylpolyalkoxybenzenes.ACS omega · 2022Article
- The Inhibitory Effect and Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 5 countries.
Funding
Abstract
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca(2+)]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca(2+)]i flux were inhibited by transient receptor potential (TRP) channel blockers. Furthermore, the most potent compound, geranylacetone, activated Ca(2+) influx in TRPV1-transfected HEK293 cells. In contrast, myristicin inhibited neutrophil [Ca(2+)]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca(2+) influx in TRPV1-transfected HEK293 cells. These findings, as well as pharmacophore modeling of TRP agonists, suggest that geranylacetone is a TRPV1 agonist, whereas myristicin is a TRPV1 antagonist. Thus, at least part of the medicinal properties of Ferula essential oils may be due to modulatory effects on TRP channels.
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