ArticleScientific reports2016
Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation.BMC biology · 2025Article
- Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease.Frontiers in cellular neuroscience · 2024Review
- The impact of spatial correlation on methylation entropy with application to mouse brain methylome.Epigenetics & chromatin · 2023Article
- Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index.Science advances · 2022Article
- Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits.Genome biology · 2021Article
- Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data.Genome biology · 2020Article
- Epigenetic regulation of neuronal cell specification inferred with single cell "Omics" data.Computational and structural biotechnology journal · 2020Article
- Virtual methylome dissection facilitated by single-cell analyses.Epigenetics & chromatin · 2019Article
- EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity.Nature communications · 2019Article
- Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells.PLoS computational biology · 2018Article
- Evaluating the Feasibility of DNA Methylation Analyses Using Long-Term Archived Brain Formalin-Fixed Paraffin-Embedded Samples.Molecular neurobiology · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
DNA methylation is an epigenetic mechanism critical for tissue development and cell specification. Mammalian brains consist of many different types of cells with assumedly distinct DNA methylation profiles, and thus some genomic loci may demonstrate bipolar DNA methylation pattern, i.e. hypermethylated in one cell subset but hypomethylated in others. Currently, how extensive methylation patterns vary among brain cells is unknown and bipolar methylated genomic loci remain largely unexplored. In this study, we implemented a procedure to infer cell-subset specific methylated (CSM) loci from the methylomes of human and mouse frontal cortices at different developmental stages. With the genome-scale hairpin bisulfite sequencing approach, we demonstrated that the majority of CSM loci predicted likely resulted from the methylation differences among brain cells rather than from asymmetric DNA methylation between DNA double strands. Correlated with enhancer-associated histone modifications, putative CSM loci increased dramatically during early stages of brain development and were enriched for GWAS variants associated with neurological disorder-related diseases/traits. Altogether, this study provides a procedure to identify genomic regions showing methylation differences in a mixed cell population and our results suggest that a set of cis-regulatory elements are primed in early postnatal life whose functions may be compromised in human neurological disorders.
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