Evidence map›Paper›PMID 27585748›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2016

Effects of Acetylcholinesterase Inhibitors on Balance and Gait Functions and Orthostatic Hypotension in Elderly Patients With Alzheimer Disease.

Ahmet Turan Isik, Pinar Soysal, Cansu Usarel

Open access · greenAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Orthostatic hypotension in patients with Alzheimer's disease: a meta-analysis of prospective studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Dysautonomia in Alzheimer's Disease.Medicina (Kaunas, Lithuania) · 2020
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ahmet Turan IsikDepartment of Geriatric Medicine, Faculty of Medicine, Center for Aging Brain and Dementia, Dokuz Eylul University, Izmir, Turkey atisik@yahoo.com.
Pinar SoysalDepartment of Geriatric Medicine, Faculty of Medicine, Center for Aging Brain and Dementia, Dokuz Eylul University, Izmir, Turkey.
Cansu UsarelDepartment of Geriatric Medicine, Faculty of Medicine, Center for Aging Brain and Dementia, Dokuz Eylul University, Izmir, Turkey.
Dokuz Eylül University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study was designed to evaluate the effect of acetylcholinesterase inhibitor (AchEI) therapy on balance, gait, and orthostatic hypotension (OH) in elderly patients with Alzheimer's disease (AD).

methodsA total of 102 elderly patients with AD have been recently diagnosed and were treated with AchEI and underwent comprehensive geriatric assessment at baseline and at the end of the sixth month.

resultsTimed Up and Go test and Tinetti Performance-Oriented Mobility Assessment values and the prevalence of OH were not different at the end of the sixth month versus baseline (P > .05). However, it was determined that changes in balance were better in the patients who showed cognitive improvement at the end of the sixth month (P < .05).

conclusionCurative effects of AchEIs, which are used in the treatment of AD, on cognitive performance are reflected also in balance functions. Moreover, it was observed that these drugs do not increase the prevalence of OH.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCholinesterase InhibitorsFemaleGaitHumansHypotension, OrthostaticMalePostural BalanceTreatment OutcomeCholinesterase Inhibitorsacetylcholine esterase inhibitorsAlzheimer’s diseasebalanceelderlygaitorthostatic hypotension

Identifiers

PMID27585748
PMCPMC10852938
OpenAlexW2516019086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.