ArticleOdontology2017
Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating.
Article in Odontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control.Bioactive materials · 2026Article
- Electrospinning Enables Opportunity for Green and Effective Antibacterial Coatings of Medical Devices.Journal of functional biomaterials · 2025Review
- Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- 3D-printed porous titanium rods equipped with vancomycin-loaded hydrogels and polycaprolactone membranes for intelligent antibacterial drug release.Scientific reports · 2024Article
- Electrospun PVP Fibers as Carriers of CaMolecules (Basel, Switzerland) · 2024Article
- Biomaterials science and surface engineering strategies for dental peri-implantitis management.Military Medical Research · 2024Review
- Advanced biomaterials for periodontal tissue regeneration.Genesis (New York, N.Y. : 2000) · 2022Review
- A Bibliometric Analysis of Electrospun Nanofibers for Dentistry.Journal of functional biomaterials · 2022Review
- Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine.Materials (Basel, Switzerland) · 2022Review
- Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications.Pharmaceutics · 2022Review
- Antimicrobial effects of nanocurcumin gel on reducing the microbial count of gingival fluids of implant‒abutment interface: A clinical study.Journal of advanced periodontology & implant dentistry · 2022Article
- Innovations in Craniofacial Bone and Periodontal Tissue Engineering - From Electrospinning to Converged Biofabrication.International materials reviews · 2022Article
- Personalized and Defect-Specific Antibiotic-Laden Scaffolds for Periodontal Infection Ablation.ACS applied materials & interfaces · 2021Article
- Implant functionalization with mesoporous silica: A promising antibacterial strategy, but does such an implant osseointegrate?Clinical and experimental dental research · 2021Article
- Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications.Materials (Basel, Switzerland) · 2021Review
- Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties.Molecules (Basel, Switzerland) · 2021Article
- The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.Clinical oral investigations · 2021Article
- Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Nature-Derived and Synthetic Additives to poly(ɛ-Caprolactone) Nanofibrous Systems for Biomedicine; an Updated Overview.Frontiers in chemistry · 2021Review
- pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Prevotella intermedia (Pi), and Aggregatibacter actinomycetemcomitans (Aa)]. Tetracycline hydrochloride (TCH) was added to a poly(DL-lactide) [PLA], poly(ε-caprolactone) [PCL], and gelatin [GEL] polymer blend solution at distinct concentrations to obtain the following fibers: PLA:PCL/GEL (TCH-free, control), PLA:PCL/GEL + 5 % TCH, PLA:PCL/GEL + 10 % TCH, and PLA:PCL/GEL + 25 % TCH. The inhibitory effect of TCH-containing fibers on biofilm formation was assessed by colony-forming units (CFU/mL). Qualitative analysis of biofilm inhibition was done via scanning electron microscopy (SEM). Statistical significance was reported at p < 0.05. Complete inhibition of biofilm formation on the fibers was observed in groups containing TCH at 10 and 25 wt%. Fibers containing TCH at 5 wt% demonstrated complete inhibition of Aa biofilm. Even though a marked reduction in CFU/mL was observed with an increase in TCH concentration, Pi proved to be the most resilient microorganism. SEM images revealed the absence of or a notable decrease in bacterial biofilm on the TCH-containing nanofibers. Collectively, our data suggest that tetracycline-containing fibers hold great potential as an antibacterial dental implant coating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.