SynthesisTherapeutic advances in respiratory disease2016
Spontaneous pneumomediastinum and subcutaneous emphysema as a complication of asthma in children: case report and literature review.
Synthesis in Therapeutic advances in respiratory disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- When Asthma Leads to Air: Pneumomediastinum in a Child.Children (Basel, Switzerland) · 2026Article
- Rapidly progressive air leak syndrome after uneventful extubation in a pediatric patient: a case report.American journal of translational research · 2026Article
- Non-invasive management of severe subcutaneous emphysema in a pediatric asthma exacerbation: a case report and review.International journal of emergency medicine · 2024Article
- A Case of Pneumomediastinum and Pneumorrhachis in a Patient With Multiple Risk Factors.Cureus · 2024Article
- Spontaneous pneumomediastinum: A comprehensive review of diagnosis and management.Intractable & rare diseases research · 2024Review
- Spontaneous pneumomediastinum with subcutaneous emphysema in a young healthy female, a case report.Heliyon · 2023Article
- Clinical features of recurrent spontaneous pneumomediastinum.Journal of thoracic disease · 2023Article
- Article
- Rare complications of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: Time to nip them in the bud.Frontiers in immunology · 2022Review
- Pneumomediastinum After COVID-19.Global pediatric health · 2022Article
- [Clinical analysis of severe cases of bronchial foreign body with mediastinal and subcutaneous emphysema in children].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Severe Spontaneous Pneumomediastinum in a Girl with Cystic Fibrosis.European journal of pediatric surgery reports · 2021Article
- A Rare Complication of Asthma: Retropharyngeal Emphysema, Subcutaneous Emphysema, and Pneumomediastinum.Cureus · 2020Article
- Pneumomediastinum and subcutaneous emphysema: a rare cause of odynophagia.BMJ case reports · 2020Article
- Subcutaneous emphysema and pneumomediastinum in child with asthma revealing occult foreign body aspiration: a case report.Journal of medical case reports · 2019Article
- Spontaneous Pneumomediastinum in a Healthy Young Male: A Case Report from Riyadh, Saudi Arabia.Cureus · 2019Article
- Spontaneous pneumomediastinum and subcutaneous emphysema in a child with unknown aetiology.BMJ case reports · 2019Article
- Case of pneumomediastinum due to alveolar rupture following endotracheal intubation.BMJ case reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous pneumomediastinum (SPM) is an uncommon disorder. It is rarely reported in paediatric patients and may be accompanied by subcutaneous emphysema. It is usually benign and self-limiting, with only supportive therapy being needed, but severe cases may require invasive measures. Asthma exacerbations have classically been described as a cause of SPM. However, detailed descriptions in asthmatic children are scarce. We aimed at improving the current understanding of the features of SPM and subcutaneous emphysema, and outcomes, by means of a case report and a systematic review.
methodsFor the systematic review a literature search was performed in PubMed to identify reported cases of SPM in asthmatic children.
resultsThe case a 10-year-old asthmatic girl with SPM is reported. The patient received an inhaled corticosteroid and long-acting beta2 agonist, in addition to sublingual immunotherapy (SLIT) with eventual control of asthma symptoms. REVIEW: A total of 114 published cases were found since 1995, most of them in teenagers; no sex differences were observed. Clinical presentation was associated with an asthma exacerbation in a number of cases. Other presenting features were chest pain, dyspnoea, cough, and particularly acute swelling of the face, neck, and upper chest. Subcutaneous emphysema was present in most patients. Overall, three cases of pneumothorax and two cases of pneumorrhachis were reported. Therapy was mainly based on supportive care, rest, oxygen therapy, analgesics, steroids, and bronchodilators. All patients recovered spontaneously, in spite of a small initial increase in SPM in a few cases.
conclusionsEarly identification of patients at risk of SPM would avoid the high number of under-diagnosed cases. Patients should be treated not only with supportive therapy but also with measures to achieve control of the underlying cause (such as poorly controlled asthma).
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