ArticleEuropean journal of nuclear medicine and molecular imaging2017
SPECT myocardial blood flow quantitation toward clinical use: a comparative study with
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Chronic remote ischemic conditioning treatment in patients with chronic stable angina (EARLY-MYO-CSA): a randomized, controlled proof-of-concept trial.BMC medicine · 2023Trial
- Quantitative and semi-quantitative comparison of myocardial blood flow betweenQuantitative imaging in medicine and surgery · 2026Article
- The Effect of Motion Correction on Quantitative Perfusion Indices and Threshold-Based Interpretation inDiagnostics (Basel, Switzerland) · 2026Article
- The impact of motion correction on quantitatively measured perfusion indices using cardiac-dedicated dynamic CZT-SPECT myocardial perfusion imaging.EJNMMI physics · 2026Article
- Feasibility of Quantitative Myocardial Perfusion with CZT SPECT and SPECT/CT: Current Limitations and Recommendations for Future Improvements.Current cardiology reports · 2026Review
- Multimodality Imaging in the Diagnosis of Coronary Microvascular Disease: An Update.Journal of personalized medicine · 2025Review
- SPECT myocardial blood flow quantitation for the detection of angiographic stenoses with cardiac-dedicated CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Associations of cardiovascular and diabetes-related risk factors with myocardial perfusion reserve assessed byThe international journal of cardiovascular imaging · 2023Article
- Prognostic value of myocardial flow reserve derived by quantitative SPECT for patients with intermediate coronary stenoses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Dose-consistent dynamic SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Anthropomorphic cardiac phantom for dynamic SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Myocardial blood flow quantitation with the SPECT technique: Where do we stand?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- A new cardiac phantom for dynamic SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Assessment of cardiac amyloidosis withEJNMMI physics · 2021Article
- Myocardial blood flow assessment with SPECT systems: The renovation continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Myocardial blood flow quantitation in patients with congestive heart failure: head-to-head comparison between rapid-rotating gantry SPECT and CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of
backgroundRecent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available. However, whether the SPECT approach can achieve the same level of accuracy as the PET approach for clinical use still needs further investigations.
methodsTwelve healthy volunteers (HVT) and 16 clinical patients with CAD received both MIBI SPECT and NH3 PET flow scans. Dynamic SPECT images acquired with high temporary resolution were fully corrected for physical factors and processed to quantify K1 using the standard compartmental modeling. Human MIBI tracer extraction fraction (EF) was determined by comparing MIBI K1 and NH3 flow on the HVT group and then used to convert flow values from K1 for all subjects. MIBI and NH3 flow values were systematically compared to validate the SPECT approach.
resultsThe human MIBI EF was determined as [1.0-0.816*exp(-0.267/MBF)]. Global and regional MBF and myocardial flow reserve (MFR) of MIBI SPECT and NH3 PET were highly correlated for all subjects (global R
conclusionsQuantitation with SPECT technologies can be accurate to measure myocardial blood flow as PET quantitation while comprehensive imaging factors of SPECT to derive the variability between these two approaches were fully addressed and corrected.
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