ArticleScientific reports2016
Curved Beam Computed Tomography based Structural Rigidity Analysis of Bones with Simulated Lytic Defect: A Comparative Study with Finite Element Analysis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Predicting the Risk for Pathological Fracture in Bone Metastases.Current oncology (Toronto, Ont.) · 2025Review
- Internal validation of modified Mirels' scoring system for pathologic femur fractures.BMC musculoskeletal disorders · 2024Article
- Computed tomography-based structural rigidity analysis can assess tumor- and treatment-induced changes in rat bones with metastatic lesions.BMC cancer · 2024Article
- Biomechanical Characteristics and Analysis Approaches of Bone and Bone Substitute Materials.Journal of functional biomaterials · 2023Review
- Fracture Risk of Long Bone Metastases: A Review of Current and New Decision-Making Tools for Prophylactic Surgery.Cancers · 2021Review
- Predicting Fracture Risk in Patients with Metastatic Bone Disease of the Femur: A Pictorial Review Using Three Different Techniques.Advances in orthopedics · 2021Article
- Biomechanical Properties of Metastatically Involved Osteolytic Bone.Current osteoporosis reports · 2020Review
- Review
- Finite element models for fracture prevention in patients with metastatic bone disease. A literature review.Bone reports · 2020Review
- Fracture risk assessment and clinical decision making for patients with metastatic bone disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- The Natural Historian's Guide to the CT Galaxy: Step-by-Step Instructions for Preparing and Analyzing Computed Tomographic (CT) Data Using Cross-Platform, Open Access Software.Integrative organismal biology (Oxford, England) · 2020Article
- Neuro-musculoskeletal flexible multibody simulation yields a framework for efficient bone failure risk assessment.Scientific reports · 2019Article
- Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer.Journal of biological engineering · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In this paper, a CT based structural rigidity analysis (CTRA) method that incorporates bone intrinsic local curvature is introduced to assess the compressive failure load of human femur with simulated lytic defects. The proposed CTRA is based on a three dimensional curved beam theory to obtain critical stresses within the human femur model. To test the proposed method, ten human cadaveric femurs with and without simulated defects were mechanically tested under axial compression to failure. Quantitative computed tomography images were acquired from the samples, and CTRA and finite element analysis were performed to obtain the failure load as well as rigidities in both straight and curved cross sections. Experimental results were compared to the results obtained from FEA and CTRA. The failure loads predicated by curved beam CTRA and FEA are in agreement with experimental results. The results also show that the proposed method is an efficient and reliable method to find both the location and magnitude of failure load. Moreover, the results show that the proposed curved CTRA outperforms the regular straight beam CTRA, which ignores the bone intrinsic curvature and can be used as a useful tool in clinical practices.
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