Evidence map›Paper›PMID 27585489›Full record

ArticleMolecular and cellular endocrinology2017

GLI1

Julia Dörner, Verena Martinez Rodriguez, Ricarda Ziegler, Theresa Röhrig, Rebecca S Cochran, Ronni M Götz, Mark D Levin, Marjut Pihlajoki, Markku Heikinheimo, David B Wilson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The Role of Gli1Biomolecules · 2023
    Review
  3. Review
  4. Effect of Inactivation ofJournal of the Endocrine Society · 2022
    Article
  5. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Julia DörnerDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Hochschule Mannheim - University of Applied Sciences, 68163 Mannheim, Germany.
Verena Martinez RodriguezDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Hochschule Mannheim - University of Applied Sciences, 68163 Mannheim, Germany.
Ricarda ZieglerDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Hochschule Mannheim - University of Applied Sciences, 68163 Mannheim, Germany.
Theresa RöhrigDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Hochschule Mannheim - University of Applied Sciences, 68163 Mannheim, Germany.
Rebecca S CochranDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA.
Ronni M GötzDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Hochschule Mannheim - University of Applied Sciences, 68163 Mannheim, Germany.
Mark D LevinDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA.
Marjut PihlajokiUniversity of Helsinki and Helsinki University Central Hospital, Children's Hospital, 00290 Helsinki, Finland.
Markku HeikinheimoDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; University of Helsinki and Helsinki University Central Hospital, Children's Hospital, 00290 Helsinki, Finland.
David B WilsonDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110 USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110 USA. Electronic address: wilson_d@wustl.edu.
Technische Hochschule Mannheim · DESt. Louis Children's Hospital · USUniversity of Helsinki · FI

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Regulation of Steroidogenic Cell Differentiation in the MouseR01DK075618 · NIDDK · WASHINGTON UNIVERSITY · PI WILSON, DAVID B · 2007 to 2011
$1.4M
A MODEL OF ATRIAL FIBRILATION TRIGGERSK08HL094748 · NHLBI · WASHINGTON UNIVERSITY · PI LEVIN, MARK DAVID · 2011 to 2014
$491k
NHLBI NIH HHS K08 HL094748NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK075618
6 · The paper itself

Abstract

As certain strains of mice age, hyperplastic lesions resembling gonadal tissue accumulate beneath the adrenal capsule. Gonadectomy (GDX) accelerates this heterotopic differentiation, resulting in the formation of wedge-shaped adrenocortical neoplasms that produce sex steroids. Stem/progenitor cells that reside in the adrenal capsule and retain properties of the adrenogonadal primordium are thought to be the source of this heterotopic tissue. Here, we demonstrate that GLI1

Indexed as

Adrenal GlandsAgingAnimalsBiomarkersCell DifferentiationCell LineageChoristomaFemaleGonadsIntegrasesMice, Inbred C57BLMice, Inbred DBAStem CellsSteroidsZinc Finger Protein GLI1BiomarkersCre recombinaseGli1 protein, mouseIntegrasesSteroidsZinc Finger Protein GLI1Adrenal cortexGonadectomyGonadotropinLineage tracingOrchiectomyOvariectomy

Identifiers

PMID27585489
PMCPMC5235954
OpenAlexW2508901978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.