Evidence map›Paper›PMID 27585401›Full record

ArticleJournal of medicinal chemistry2016

Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Christopher P Gordon, Shondra D Olson, Jessica L Lister, Jeffrey S Kavanaugh, Alexander R Horswill

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. [Research Progress on Quorum Sensing-Regulated Oral Microbial Interaction Networks in Periodontitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Article
  5. Molecular Mechanisms of Virulence Regulation inAccounts of chemical research · 2025
    Article
  6. Biofilm · 2024
    Review
  7. Article
  8. A Review of Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Biofilm and Small Colony Variants-An Update onInternational journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Christopher P GordonSchool of Science and Health, Western Sydney University , Locked Bag 1797, Penrith South Dc, NSW 2751, Australia.
Shondra D OlsonDepartment of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa 52242, United States.
Jessica L ListerDepartment of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa 52242, United States.
Jeffrey S KavanaughDepartment of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa 52242, United States.
Alexander R HorswillDepartment of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, Iowa 52242, United States.
University of Iowa · USWestern Sydney University · AU

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Competitive quorum sensing (QS) antagonism offers a novel strategy for attenuating current multidrug resistant staphylococcal infections. To this end, a series of 10 truncated analogues based on the parent autoinducing peptides (AIPs) of Staphylococcus lugdunensis (groups I and II) and Staphylococcus epidermidis (groups I-III) were sequentially assessed against a newly developed Staphylococcus lugdunensis group I QS reporter strain. The truncated analogues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDrug DiscoveryHumansModels, MolecularPeptides, CyclicQuorum SensingStaphylococcal InfectionsStaphylococcus epidermidisStaphylococcus lugdunensisAgrD protein, StaphylococcusAnti-Bacterial AgentsBacterial ProteinsPeptides, Cyclic

Identifiers

PMID27585401
PMCPMC5234682
OpenAlexW2519606469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.