ArticleAmerican journal of respiratory and critical care medicine2016
A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
94 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- Socioeconomic circumstances and respiratory function from childhood to early adulthood: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Prediction models for the development of COPD: a systematic review.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- Early life insults as determinants of chronic obstructive pulmonary disease in adult life.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial.American journal of respiratory and critical care medicine · 2019Trial
- Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.International journal of environmental research and public health · 2018Trial
- Observational
- Altered expression of Toll-like receptor 9 in the lung tissue of adult mice generated by in vitro embryo culture and embryo transfer.Histochemistry and cell biology · 2026Article
- Lung function across the life course in Kenya: a series of cross-sectional surveys.ERJ open research · 2026Article
- Pulmonary function trajectories in children with symptom-controlled asthma -a 10-year retrospective cohort study in China.BMC pulmonary medicine · 2026Article
- Long-term pulmonary outcomes in BPD throughout the life-course.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Article
- Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population.International journal of chronic obstructive pulmonary disease · 2026Article
- Clustering lung function and symptom profiles for asthma risk stratification.Scientific reports · 2025Article
- Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Review
- Respiratory distress syndrome is the poster child for neonatology.Pediatric research · 2025Article
- Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood-A Prospective Cohort Study.Clinical and translational allergy · 2025Article
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
rationaleLow maximally attained lung function increases the risk of chronic obstructive pulmonary disease irrespective of the subsequent rate of lung function decline.
objectivesWe aimed to determine if there were individuals with a distinct, persistently low lung function trajectory in the CRS (Tucson Children's Respiratory Study).
methodsThe CRS, an ongoing birth cohort study, enrolled 1,246 participants between 1980 and 1984. Latent class linear mixed effects modeling of the ratio of FEV1 to FVC was used to identify distinct lung function trajectories among participants with two or more spirometry measurements between ages 11 and 32 years. MEASUREMENTS AND MAIN
resultsAmong 599 participants with 2,142 observations, a model with two distinct trajectories (a low trajectory [n = 56; 9.3%] and a normal trajectory) fit the data significantly better than a model with only one trajectory (P = 0.0007). As compared with those with a normal trajectory, participants with a persistently low trajectory were more likely to have a history of maternal asthma (20.0% vs. 9.9%; P = 0.02); early life lower respiratory illness caused by respiratory syncytial virus (41.2% vs. 21.4%; P = 0.001); and physician-diagnosed active asthma at age 32 years (43.9% vs. 16.2%; P < 0.001). Individuals with a persistently low trajectory also demonstrated lower lung function as measured by average maximal expiratory flow at functional residual capacity during infancy and at age 6 years.
conclusionsA distinct group of individuals in a nonselected population demonstrates a persistently low lung function trajectory that may be partly established at birth and predisposes them to chronic obstructive pulmonary disease later in life.
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