ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Genipin crosslinking decreases the mechanical wear and biochemical degradation of impacted cartilage in vitro.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Influence of k-wire placement on impact mechanics and bone fracture in a rabbit model of cartilage injury.PloS one · 2026Article
- Hydroxyapatite microspheres induce durable pleurodesis and are rapidly cleared by pleural osteoclasts.JCI insight · 2025Article
- In Vitro Impact Model to Generate Sublethal Chondrocyte Injury in Bovine Cartilage Explants.Journal of visualized experiments : JoVE · 2025Article
- Mechanical Wear of Degraded Articular Cartilage.Annals of biomedical engineering · 2025Article
- Exogenous Collagen Crosslinking is Highly Detrimental to Articular Cartilage Lubrication.Journal of biomechanical engineering · 2024Article
- A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit.Journal of visualized experiments : JoVE · 2023Article
- Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel.Bioengineering (Basel, Switzerland) · 2023Article
- Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.Journal of the mechanical behavior of biomedical materials · 2023Article
- Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload.International journal of molecular sciences · 2023Article
- Genipin does not reduce the initiation or propagation of microcracks in collagen networks of cartilage.Osteoarthritis and cartilage open · 2022Article
- Cross-linking methods of type I collagen-based scaffolds for cartilage tissue engineering.American journal of translational research · 2022Review
- Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.Advanced healthcare materials · 2021Article
- Anisotropic properties of articular cartilage in an accelerated in vitro wear test.Journal of the mechanical behavior of biomedical materials · 2020Article
- Article
- Regeneration of skeletal system with genipin crosslinked biomaterials.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
High energy trauma to cartilage causes surface fissures and microstructural damage, but the degree to which this damage renders the tissue more susceptible to wear and contributes to the progression of post-traumatic osteoarthritis (PTOA) is unknown. Additionally, no treatments are currently available to strengthen cartilage after joint trauma and to protect the tissue from subsequent degradation and wear. The purposes of this study were to investigate the role of mechanical damage in the degradation and wear of cartilage, to evaluate the effects of impact and subsequent genipin crosslinking on the changes in the viscoelastic parameters of articular cartilage, and to test the hypothesis that genipin crosslinking is an effective treatment to enhance the resistance to biochemical degradation and mechanical wear. Results demonstrate that cartilage stiffness decreases after impact loading, likely due to the formation of fissures and microarchitectural damage, and is partially or fully restored by crosslinking. The wear resistance of impacted articular cartilage was diminished compared to undamaged cartilage, suggesting that mechanical damage that is directly induced by the impact may contribute to the progression of PTOA. However, the decrease in wear resistance was completely reversed by the crosslinking treatments. Additionally, the crosslinking treatments improved the resistance to collagenase digestion at the impact-damaged articular surface. These results highlight the potential therapeutic value of collagen crosslinking via genipin in the prevention of cartilage degeneration after traumatic injury. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:558-565, 2017.
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Registered trials
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