ArticlePLoS computational biology2016
A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Histamine regulation in shaping spindle refractoriness: a computational modeling study.Journal of computational neuroscience · 2026Article
- Artificial intelligence as a surrogate brain: bridging neural dynamical models and data.National science review · 2026Review
- Cortical connectivity, local dynamics and stability correlates of global conscious states.Communications biology · 2025Article
- Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy.Cognitive neurodynamics · 2024Article
- Uncovering the organization of neural circuits with Generalized Phase Locking Analysis.PLoS computational biology · 2023Article
- Dynamic causal modelling shows a prominent role of local inhibition in alpha power modulation in higher visual cortex.PLoS computational biology · 2022Article
- Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics.Frontiers in network physiology · 2022Article
- Cross-Frequency Slow Oscillation-Spindle Coupling in a Biophysically Realistic Thalamocortical Neural Mass Model.Frontiers in computational neuroscience · 2022Article
- A model of metabolic supply-demand mismatch leading to secondary brain injury.Journal of neurophysiology · 2021Article
- Real-Time Excitation of Slow Oscillations during Deep Sleep Using Acoustic Stimulation.Sensors (Basel, Switzerland) · 2021Article
- Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.PLoS computational biology · 2021Article
- Computational Evidence for a Competitive Thalamocortical Model of Spikes and Spindle Activity in Rolandic Epilepsy.Frontiers in computational neuroscience · 2021Article
- Simulating human sleep spindle MEG and EEG from ion channel and circuit level dynamics.Journal of neuroscience methods · 2019Article
- Sleep Modelling across Physiological Levels.Clocks & sleep · 2019Review
- Effects of Cholinergic Neuromodulation on Thalamocortical Rhythms During NREM Sleep: A Model Study.Frontiers in computational neuroscience · 2019Article
- Sleep Spindle Refractoriness Segregates Periods of Memory Reactivation.Current biology : CB · 2018Article
- Classifying dynamic transitions in high dimensional neural mass models: A random forest approach.PLoS computational biology · 2018Article
- A new description of epileptic seizures based on dynamic analysis of a thalamocortical model.Scientific reports · 2017Article
- Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.PLoS computational biology · 2017Article
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7 authors.
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Abstract
Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. Here, we present a neural mass model of the thalamocortical system during natural non-REM sleep, which is able to generate fast sleep spindles (12-15 Hz), slow oscillations (<1 Hz) and K-complexes, as well as their distinct temporal relations, and response to auditory stimuli. We show that with the inclusion of detailed calcium currents, the thalamic neural mass model is able to generate different firing modes, and validate the model with EEG-data from a recent sleep study in humans, where closed-loop auditory stimulation was applied. The model output relates directly to the EEG, which makes it a useful basis to develop new stimulation protocols.
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