Evidence map›Paper›PMID 27584691›Full record

ArticleEmerging infectious diseases2016

Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome.

Laura Grande, Valeria Michelacci, Roslen Bondì, Federica Gigliucci, Eelco Franz, Mahdi Askari Badouei, Sabine Schlager, Fabio Minelli, Rosangela Tozzoli, Alfredo Caprioli and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Intestinal Carriage of Two DistinctPathogens (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Shiga Toxin-ProducingMicroorganisms · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Population Analysis of O26 Shiga Toxin-ProducingFrontiers in cellular and infection microbiology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. The European Union One Health 2018 Zoonoses Report.EFSA journal. European Food Safety Authority · 2019
    Article
  13. Article
  14. Article
  15. Presence of Shiga Toxin-ProducingMicroorganisms · 2018
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Laura Grande
Valeria Michelacci
Roslen Bondì
Federica Gigliucci
Eelco Franz
Mahdi Askari Badouei
Sabine Schlager
Fabio Minelli
Rosangela Tozzoli
Alfredo Caprioli
Stefano Morabito
Austrian Agency for Health and Food Safety · ATIslamic Azad University of Garmsar · IRIstituto Superiore di Sanità · ITIslamic Azad University, Tehran · IRNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Verotoxigenic Escherichia coli infections in humans cause disease ranging from uncomplicated intestinal illnesses to bloody diarrhea and systemic sequelae, such as hemolytic uremic syndrome (HUS). Previous research indicated that pigeons may be a reservoir for a population of verotoxigenic E. coli producing the VT2f variant. We used whole-genome sequencing to characterize a set of VT2f-producing E. coli strains from human patients with diarrhea or HUS and from healthy pigeons. We describe a phage conveying the vtx2f genes and provide evidence that the strains causing milder diarrheal disease may be transmitted to humans from pigeons. The strains causing HUS could derive from VT2f phage acquisition by E. coli strains with a virulence genes asset resembling that of typical HUS-associated verotoxigenic E. coli.

Indexed as

Genome, BacterialGenomicsAnimalsBacteriophagesHemolytic-Uremic SyndromeHumansPhylogenyPolymorphism, Single NucleotideSerogroupShiga-Toxigenic Escherichia coliShiga Toxin 2VirulenceWhole Genome SequencingShiga Toxin 2bacteriaenteric infectionsEscherichia colievolutionhemolytic uremic syndromeHUSvariant verotoxigenic Escherichia colivirulenceVT2f-producingVTECwhole-genome characterizationzoonoses

Identifiers

PMID27584691
PMCPMC5189129
OpenAlexW2515018609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.