ArticlePloS one2016
Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Utility of Diffusion Weighted Magnetic Resonance Imaging in Early Detection and Staging of Acute Pancreatitis: Correlation with Revised Atlanta ClassificationCurrent medical imaging · 2026Article
- Diffusion tensor imaging and diffusion kurtosis imaging of the pancreas - feasibility, robustness and protocol comparison in a healthy population.Abdominal radiology (New York) · 2025Article
- Quantitative pancreatic MRI: a pathology-based review.The British journal of radiology · 2019Review
- MR imaging for acute pancreatitis: the current status of clinical applications.Annals of translational medicine · 2019Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the feasibility of differentiating between acute pancreatitis (AP) and healthy pancreas using diffusion tensor imaging (DTI) and correlate apparent diffusion coefficient (ADC) /fractional anisotropy (FA) values with the severity of AP. MATERIAL AND
methods66 patients diagnosed with AP and 20 normal controls (NC) underwent DTI sequences and routine pancreatic MR sequences on a 3.0T MRI scanner. Average ADC and FA values of the pancreatic were measured. Differences of FA and ADC values between the AP group and the NC group with AP and healthy pancreas were compared by two-sample independent t-test. The severity of AP on MRI was classified into subgroups using MR severity index (MRSI), where the mean FA and ADC values were calculated. Relationship among the FA values, ADC values and MRSI were analyzed using Spearman's rank correlation coefficients.
resultsThe pancreatic mean ADC value in the AP group (1.68 ± 0.45×10-3mm2/s) was significantly lower than in the NC group (2.09 ± 0.55×10-3mm2/s) (P = 0.02); the same as mean FA value (0.39 ± 0.23 vs 0.54 ± 0.12, P = 0.00). In the subgroup analysis, the pancreatic ADC and FA value of edema AP patients was significantly higher than necrosis AP patients with P = 0.000 and P = 0.001respectively. In addition, as severity of pancreatitis increased according to MRSI, lower pancreatic ADC (r = -0.635) and FA value (r = -0.654) were noted.
conclusionBoth FA and ADC value from DTI can be used to differentiate AP patients from NC. Both ADC and FA value of pancreas have a negative correlation with the severity of AP.
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