ArticleMedicine2016
Association of chemerin levels and bone mineral density in Chinese obese postmenopausal women.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Association of Chemerin, follicle stimulating hormone, lipid profiles, and cardiometabolic indices with the premature ovarian insufficiency.Scientific reports · 2026Article
- The role of adipokines in osteoporosis management: a mini review.Frontiers in endocrinology · 2024Review
- Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition.Metabolites · 2023Review
- Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review.Biomedicines · 2023Review
- The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results.Frontiers in endocrinology · 2023Article
- Association of High Serum Chemerin with Bone Mineral Density Loss and Osteoporotic Fracture in Elderly Chinese Women.International journal of women's health · 2022Article
- Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females.Frontiers in endocrinology · 2022Article
- The Evaluation of Bone Mineral Density based on Age and Anthropometric Parameters in Southeast Chinese Adults: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- The cross-sectional association between chemerin and bone health in peri/pre and postmenopausal women: results from the EPIC-Potsdam study.Menopause (New York, N.Y.) · 2018Article
- Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice.Journal of orthopaedic translation · 2017Article
- Adipokines may mediate the relationship between resting metabolic rates and bone mineral densities in obese women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Erratum: Association of chemerin levels and bone mineral density in Chinese obese postmenopausal women: Erratum.Medicine · 2016Article
- Association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal females.Pakistan journal of medical sciencesArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests the association between obesity and bone metabolism. However, whether excessive fat accumulation has a beneficial or adverse effect on bone health remains controversial. Chemerin is a novel adipocyte-derived hormone and a chemoattractant cytokine that regulates adipogenesis. This study was performed to investigate the associations of serum chemerin with bone mineral density (BMD) and serum pro-inflammatory cytokine levels in 543 Chinese obese postmenopausal women. BMD of the femoral neck and lumbar spine, lean mass, and fat mass were measured using dual energy X-ray absorptiometry. Anthropometric assessment and laboratory measurements were performed. The age, time after menopause, and fat mass were negatively correlated with femoral and lumbar BMD, whereas lean mass was positively correlated with aforementioned variables. Furthermore, BMD at the lumbar spine was inversely associated with serum chemerin and TNF-α levels (r = -0.155, P = 0.001; r = -0.147, P = 0.001). Multiple linear regression analyses showed that serum chemerin levels were negatively correlated with BMD at the lumbar site after controlling for the age, lean, and fat mass (β = -0.125, P = 0.001). Chronic low-grade inflammation state in obese population has an inverse effect on bone mass. Chemerin as an adipocytokine and chemoattractant negatively affects the bone mass of Chinese obese postmenopausal women. Further studies are needed to confirm the potential role of chemerin in the crosstalk between bone and fat accumulation in obese population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.