Evidence map›Paper›PMID 27583388›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2016

Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation.

L Gemmell, L Martin, K E Murphy, N Modi, S Håkansson, B Reichman, K Lui, S Kusuda, G Sjörs, L Mirea and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Pooled it
  7. Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Trial
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  13. The relationship between severe hypertensive diseases of pregnancy and moderate-severe bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

L GemmellCanadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
L MartinCanadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
K E MurphyDepartment of Obstetrics and Gynecology, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
N ModiUK Neonatal Collaborative, Neonatal Data Analysis Unit, Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK.
S HåkanssonSwedish Neonatal Quality Register, Department of Pediatrics/Neonatal Services, Umeå University Hospital, Umeå, Sweden.
B ReichmanIsrael Neonatal Network, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Centre, Tel Hashomer, Israel.
K LuiAustralian and New Zealand Neonatal Network, Royal Hospital for Women, National Perinatal Epidemiology and Statistic Unit, University of New South Wales, Randwick, New South Wales, Australia.
S KusudaNeonatal Research Network Japan, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan.
G SjörsSwedish Neonatal Quality Register, Uppsala University, Department of Women's and Children's Health, Uppsala, Sweden.
L MireaCanadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
B A DarlowAustralia and New Zealand Neonatal Network, Department of Paediatrics, University of Otago, Christchurch, New Zealand.
R MoriNeonatal Research Network Japan, Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
S K LeeCanadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
P S ShahCanadian Neonatal Network, Maternal-Infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.

Funding

CIHR APR-126340Department of Health RP-PG-0707-10010
6 · The paper itself

Abstract

objectiveTo examine the relationship between hypertensive disorders of pregnancy (HDPs) and mortality and major morbidities in preterm neonates born at 24 to 28 weeks of gestation. STUDY

designUsing an international cohort, we retrospectively studied 27 846 preterm neonates born at 24

resultsThe incidence of HDP in the entire cohort was 13% (range 11 to 16% across countries). HDP was associated with reduced odds of mortality (adjusted odds ratio (aOR) 0.77; 95% confidence interval (CI) 0.67 to 0.88), severe brain injury (aOR 0.74; 95% CI 0.62 to 0.89) and treated retinopathy (aOR 0.82; 95% CI 0.70 to 0.96), but increased odds of bronchopulmonary dysplasia (aOR 1.16; 95% CI 1.05 to 1.27).

conclusionsIn comparison with neonates born to mothers without HDP, neonates of HDP mothers had lower odds of mortality, severe brain injury and treated retinopathy, but higher odds of bronchopulmonary dysplasia. The impact of maternal HDP on newborn outcomes was inconsistent across outcomes and among countries; therefore, further international collaboration to standardize terminology, case definition and data capture is warranted.

Indexed as

Infant, Extremely PrematureBirth InjuriesBronchopulmonary DysplasiaCase-Control StudiesDatabases, FactualEnterocolitis, NecrotizingFemaleGestational AgeHumansHypertension, Pregnancy-InducedIncidenceInfantInfant MortalityInfant, NewbornLogistic ModelsOdds Ratio

Identifiers

PMID27583388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.