ArticlePLoS genetics2016
A P-Loop NTPase Regulates Quiescent Center Cell Division and Distal Stem Cell Identity through the Regulation of ROS Homeostasis in Arabidopsis Root.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 96 citations in OpenAlex.
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- WOX11-OsPRX130 module confers rice drought tolerance by maintaining ROS homeostasis in rice root.Rice (New York, N.Y.) · 2025Article
- The MADS-box gene XAANTAL1 participates in Arabidopsis thaliana primary root growth and columella stem cell patterns in response to ROS, via direct regulation of PEROXIDASE 28 and RETINOBLASTOMA-RELATED genes.Journal of experimental botany · 2025Article
- Article
- ROS, an Important Plant Growth Regulator in Root Growth and Development: Functional Genes and Mechanism.Biology · 2024Review
- ATP Hydrolases Superfamily Protein 1 (ASP1) Maintains Root Stem Cell Niche Identity through Regulating Reactive Oxygen Species Signaling inPlants (Basel, Switzerland) · 2024Article
- Hydrogen Peroxide Signaling in the Maintenance of Plant Root Apical Meristem Activity.Antioxidants (Basel, Switzerland) · 2024Review
- Transcriptome analysis reveals the effect of propyl gallate on kiwifruit callus formation.Plant cell reports · 2024Article
- TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots.Frontiers in plant science · 2024Article
- Preserving root stem cell functionality under low oxygen stress: the role of nitric oxide and phytoglobins.Planta · 2023Review
- ROS-stimulated protein lysine acetylation is required for crown root development in rice.Journal of advanced research · 2023Article
- SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling.Plant physiology · 2023Article
- Reactive oxygen metabolism in the proliferation of Korean pine embryogenic callus cells promoted by exogenous GSH.Scientific reports · 2023Article
- Making watercress (Frontiers in plant science · 2023Article
- Genome-wide identification and expression analysis of GDP-D-mannose pyrophosphorylase and KATANIN inFrontiers in plant science · 2023Article
- Interplay between Proline Metabolism and ROS in the Fine Tuning of Root-Meristem Size inPlants (Basel, Switzerland) · 2022Article
- High-LD SNP markers exhibiting pleiotropic effects on salt tolerance at germination and seedlings stages in spring wheat.Plant molecular biology · 2022Article
- Salicylic Acid in Root Growth and Development.International journal of molecular sciences · 2022Review
- The interaction of ABA and ROS in plant growth and stress resistances.Frontiers in plant science · 2022Review
- Transcriptomic Profiling Provides Molecular Insights Into Hydrogen Peroxide-EnhancedFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) are recognized as important regulators of cell division and differentiation. The Arabidopsis thaliana P-loop NTPase encoded by APP1 affects root stem cell niche identity through its control of local ROS homeostasis. The disruption of APP1 is accompanied by a reduction in ROS level, a rise in the rate of cell division in the quiescent center (QC) and the promotion of root distal stem cell (DSC) differentiation. Both the higher level of ROS induced in the app1 mutant by exposure to methyl viologen (MV), and treatment with hydrogen peroxide (H2O2) rescued the mutant phenotype, implying that both the increased rate of cell division in the QC and the enhancement in root DSC differentiation can be attributed to a low level of ROS. APP1 is expressed in the root apical meristem cell mitochondria, and its product is associated with ATP hydrolase activity. The key transcription factors, which are defining root distal stem niche, such as SCARECROW (SCR) and SHORT ROOT (SHR) are both significantly down-regulated at both the transcriptional and protein level in the app1 mutant, indicating that SHR and SCR are important downstream targets of APP1-regulated ROS signaling to control the identity of root QC and DSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.