ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
The hOGG1 Ser326Cys gene polymorphism and susceptibility for bladder cancer: a meta-analysis.
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage.Iranian biomedical journal · 2021Article
- Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer.Oncology letters · 2019Article
- The hOGG1 Ser326Cys polymorphism and esophageal cancer risk: a meta-analysis of 1,875 cancer cases and 3,041 controls.Annals of translational medicine · 2019Article
- Systematic Review: Genetic Associations for Prognostic Factors of Urinary Bladder Cancer.Biomarkers in cancer · 2019Review
- DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms.Oncology letters · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the susceptibility of the hOGG1 genetic polymorphism for bladder cancer and evaluate the impact of smoking exposure. MATERIALS AND
methodsArticles included in PubMed, Medline and Springer databases were retrieved using the following key words: "human 8-oxoguanine DNA glycosyl¬ase", "OGG", "OGG1", "hOGG1", "genetic variation", "polymorphism" , "bladder cancer", and "bladder carcinoma" to Meta-analysis was performed to detect whether there were differences between the bladder cancer group and the control group about the distribution of genotypes of the hOGG1 gene.
resultsThe results showed that there are no significant associations between the hOGG1 326Cys polymorphism and bladder cancer: GG vs CC (OR: 1.09, 95% CI: 0.85- 1.40, p=0.480); GC vs CC (OR: 1.05, 95% CI: 0.85-1.28, p=0.662); GG+GC vs CC (OR: 1.04, 95% CI: 0.89-1.21, p=0.619); GG vs GC+CC (OR: 1.02, 95% CI: 0.78-1.33, p=0.888); G vs C (OR: 1.01, 95% CI: 0.91-1.13, p=0.818). In the smoker population, no significant associations between the hOGG1 326Cys polymorphism and bladder cancer were observed for all the models. However, individuals carrying the hOGG1 Cys326Cys genotype have increased risk for bladder cancer compared to those carrying the hOGG1 Ser326Ser genotype in the non-smoker Asian population.
conclusionThe hOGG1 326Cys polymorphisms aren't a risk factor for bladder cancer, especially in the smoker population. But GG genotype is a risk factor for bladder cancer to the non-smoker Asian population compared with CC genotype.
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