ArticleTemperature (Austin, Tex.)
Heat stress causes oxidative stress but not inflammatory signaling in porcine skeletal muscle.
Article in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 124 citations in OpenAlex.
- Dynamic responses in the human methylome to exertional heat exhaustion, heat injury, and heat stroke.Human genomics · 2026Article
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- Variations in Diacron-Reactive Oxygen Metabolites and Biological Antioxidant Potential Across Reproductive Phases and Parities in Sows Reared Under Different Production Systems.Animals : an open access journal from MDPI · 2025Article
- Heat Stress-Mediated Multi-Organ Injury: Pathophysiology and Treatment Strategies.Comprehensive Physiology · 2025Review
- Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights.Veterinary world · 2025Article
- Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress.Nature communications · 2025Article
- Impact of Heat Stress on Carcass Traits, Meat Quality, and Nutritional Value in Monogastric Animals: Underlying Mechanisms and Nutritional Mitigation Strategies.Foods (Basel, Switzerland) · 2025Review
- Review
- Article
- Biological sex impacts oxidative stress in skeletal muscle in a porcine heat stress model.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Effect of the Season on Blood Changes of Oxidative Stress Index in the Italian Mediterranean Buffalo (Veterinary sciences · 2024Article
- Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions.Journal of animal science and biotechnology · 2024Article
- Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?Journal of animal science and biotechnology · 2024Review
- Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine.BMC genomics · 2024Article
- Role of vitamin E on bovine skeletal-muscle-derived cells from Korean native cattle under heat treatment.Journal of animal science · 2024Article
- Heat stress alters hematological parameters in barrows and gilts.Journal of animal science · 2024Article
- Therapeutic effect of Yinhuapinggan granules mediated through the intestinal flora in mice infected with the H1N1 influenza virus.Frontiers in microbiology · 2024Article
- Insect Peptide CopA3 Mitigates the Effects of Heat Stress on Porcine Muscle Satellite Cells.Animals : an open access journal from MDPI · 2023Article
- The biological functions and metabolic pathways of valine in swine.Journal of animal science and biotechnology · 2023Review
- Physicochemical Properties, Antioxidant Markers, and Meat Quality as Affected by Heat Stress: A Review.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress is associated with death and other maladaptions including muscle dysfunction and impaired growth across species. Despite this common observation, the molecular effects leading to these pathologic changes remain unclear. The purpose of this study was to determine the extent to which heat stress disrupted redox balance and initiated an inflammatory response in oxidative and glycolytic skeletal muscle. Female pigs (5-6/group) were subjected to thermoneutral (20 °C) or heat stress (35 °C) conditions for 1 or 3 days and the semitendinosus removed and dissected into red (STR) and white (STW) portions. After 1 day of heat stress, relative abundance of proteins modified by malondialdehyde, a measure of oxidative damage, was increased 2.5-fold (P < 0.05) compared with thermoneutral in the STR but not the STW, before returning to thermoneutral conditions following 3 days of heat stress. This corresponded with increased catalase and superoxide dismutase-1 gene expression (P < 0.05) and superoxide dismutase-1 protein abundance (P < 0.05) in the STR but not the STW. In the STR catalase and total superoxide dismutase activity were increased by ~30% and ~130%, respectively (P < 0.05), after 1 day of heat stress and returned to thermoneutral levels by day 3. One or 3 days of heat stress did not increase inflammatory signaling through the NF-κB pathway in the STR or STW. These data suggest that oxidative muscle is more susceptible to heat stress-mediated changes in redox balance than glycolytic muscle during chronic heat stress.
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Registered trials
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