Evidence map›Paper›PMID 27583210›Full record

ArticleJournal of developmental biology2016

Mechanisms of Specificity for Hox Factor Activity.

Arya Zandvakili, Brian Gebelein

Abstract read
In one paragraph

Article in Journal of developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization.International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Transcriptional Regulation and Implications for ControllingJournal of developmental biology · 2022
    Review
  6. Article
  7. Article
  8. Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Protein phosphatases in chromatin structure and function.Biochimica et biophysica acta. Molecular cell research · 2019
    Review
  13. Article
  14. Engineering the Drosophila Genome for Developmental Biology.Journal of developmental biology · 2017
    Review
  15. Article
  16. Special Issue on HOX Genes in Development.Journal of developmental biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arya ZandvakiliMolecular and Developmental Biology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Medical-Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Brian GebeleinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Mechanisms of Homeodomain Transcriptional SpecificityR01GM079428 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI GEBELEIN, BRIAN · 2008 to 2023
$4.5M
NIGMS NIH HHS R01 GM079428NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Metazoans encode clusters of paralogous Hox genes that are critical for proper development of the body plan. However, there are a number of unresolved issues regarding how paralogous Hox factors achieve specificity to control distinct cell fates. First, how do Hox paralogs, which have very similar DNA binding preferences

Indexed as

cis-regulatory modulesDNA binding specificityHoxtranscription factor

Identifiers

PMID27583210
PMCPMC5003318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.