ReviewTherapeutic advances in neurological disorders2016
Poststroke epilepsy: update and future directions.
Review in Therapeutic advances in neurological disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk factors of post-stroke epilepsy among pediatric population: a systematic review.Frontiers in neurology · 2025Pooled it
- Common Pathways of Epileptogenesis in Patients With Epilepsy Post-Brain Injury: Findings From a Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Trial
- Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease.CNS neuroscience & therapeutics · 2019Trial
- Post-Stroke Epileptogenesis as a Dynamic Network Process: State-Dependent Biomarkers, Longitudinal Monitoring, and the Concept of an Irritable Brain State.International journal of molecular sciences · 2026Review
- Effects of Clopidogrel on the Anticonvulsant Efficacy of Valproic Acid and Levetiracetam in a PTZ-Induced Seizure Model.International journal of molecular sciences · 2026Article
- Neurorehabilitation for cognitive and motor recovery: mechanisms, interventions, and translational advances.Frontiers in neurology · 2026Review
- Navigating pediatric post-stroke epilepsy: comparative assessment of treatment strategies.Acta neurologica Belgica · 2025Article
- Statins' protective effects on focal epilepsy are independent of LDL-C.Epilepsia open · 2025Article
- Exploratory study of blood biomarkers in patients with post-stroke epilepsy.European stroke journal · 2024Article
- Clinical approaches for poststroke seizure: a review.Frontiers in neurology · 2024Review
- The Primary Prevention of Poststroke Epilepsy in Patients With Middle Cerebral Artery Infarct: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Article
- Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke.Stroke · 2023Article
- Childhood strokes in China describing clinical characteristics, risk factors and performance indicators: a case-series study.Stroke and vascular neurology · 2022Article
- Seizures and epilepsy in patients with ischaemic stroke.Neurological research and practice · 2021Review
- Antiseizure medications for post-stroke epilepsy: A real-world prospective cohort study.Brain and behavior · 2021Article
- Poststroke epilepsy incidence, risk factors and treatment: German claims analysis.Acta neurologica Scandinavica · 2021Article
- Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.Drugs & aging · 2021Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is among the most common causes of epilepsy after middle age. Patients with poststroke epilepsy (PSE) differ in several respects from patients with other forms of structural-metabolic epilepsy; not least in age, age-related sensitivity to side effects of antiepileptic drugs (AEDs), and specific drug-drug interaction issues related to secondary-stroke prophylaxis. Encouragingly, there has lately been remarkable activity in the study of PSE. Three developments in PSE research deserve particular focus. First, large prospective trials have established the incidence and risk factors of PSE in the setting of modern stroke care. Stroke severity, cortical location, young age, and haemorrhage remain the most important risk factors. Second, although more studies are needed, epidemiological data indicate that the risk of PSE may be influenced, for instance, by statin treatment. Third, studies are emerging regarding the treatment and prognosis of PSE. Levetiracetam and lamotrigine may be well tolerated treatment options and seizure freedom is achieved in at least a similar proportion of patients as in other epilepsies. Furthermore, new animal models such as photothrombotic stroke gives hope of a more clear understanding of PSE epileptogenesis in the near future. In summary, PSE shows indications of maturing into an independent epilepsy research field. This review summarizes recent advances in our understanding of PSE and provides an update on management issues such as diagnosis, AED selection, and prognosis. Finally, future research challenges in the field are outlined.
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