Evidence map›Paper›PMID 27582879›Full record

ArticleTherapeutic advances in gastroenterology2016

Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study.

Anton Pottegård, Anne Broe, Jesper Hallas, Ove B Schaffalitzky de Muckadell, Annmarie T Lassen, Anders B Lødrup

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  4. Interchangeable Use of Proton Pump Inhibitors Based on Relative Potency.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018
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  14. Use of Proton Pump Inhibitors Among Patients With Alcohol-Related Cirrhosis-A Danish Nationwide Cohort Study.Liver international : official journal of the International Association for the Study of the Liver · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anton PottegårdClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark.
Anne BroeClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark.
Jesper HallasClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark Department of Clinical Chemistry & Pharmacology, Odense University Hospital.
Ove B Schaffalitzky de MuckadellDepartment of Medical Gastroenterology, Odense University Hospital, Denmark.
Annmarie T LassenDepartment of Emergency Medicine, Odense University Hospital, Denmark.
Anders B LødrupDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Nørrebrogade 44, Aarhus, 8000, Denmark.
Odense University Hospital · DKUniversity of Southern Denmark · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of proton-pump inhibitors (PPIs) has increased over the last decade. The objective of this study was to provide detailed utilization data on PPI use over time, with special emphasis on duration of PPI use and concomitant use of ulcerogenic drugs.

methodsUsing the nationwide Danish Prescription Registry, we identified all Danish adults filling a PPI between 2002 and 2014. Using descriptive statistics, we reported (i) the distribution of use between single PPI entities, (ii) the development in incidence and prevalence of use over time, (iii) measures of duration and intensity of treatment, and (iv) the prevalence of use of ulcerogenic drugs among users of PPIs.

resultsWe identified 1,617,614 adults using PPIs during the study period. The prevalence of PPI use increased fourfold during the study period to 7.4% of all Danish adults in 2014. PPI use showed strong age dependency, reaching more than 20% among those aged at least 80 years. The proportion of users maintaining treatment over time increased with increasing age, with less than10% of those aged 18-39 years using PPIs 2 years after their first prescription, compared with about 40% among those aged at least 80 years. The overall use of ulcerogenic drugs among PPI users increased moderately, from 35% of users of PPI in 2002 to 45% in 2014.

conclusionsThe use of PPIs is extensive and increasing rapidly, especially among the elderly.

Indexed as

general populationincidenceprescription registryprevalenceproton-pump inhibitorulcerogenic drugs

Identifiers

PMID27582879
PMCPMC4984329
OpenAlexW2401431951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.