ReviewFrontiers in neural circuits2016
Interneuron Progenitor Transplantation to Treat CNS Dysfunction.
Review in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Application of Medial Ganglionic Eminence Cell Transplantation in Diseases Associated With Interneuron Disorders.Frontiers in cellular neuroscience · 2022Review
- Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex.Nature communications · 2021Article
- Molecular expression profiles of morphologically defined hippocampal neuron types: Empirical evidence and relational inferences.Hippocampus · 2020Article
- Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells.PloS one · 2020Article
- Direct reprogramming into interneurons: potential for brain repair.Cellular and molecular life sciences : CMLS · 2019Review
- CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Opportunities and challenges in psychopharmacology .Dialogues in clinical neuroscience · 2019Review
- Cortical GABAergic Interneuron/Progenitor Transplantation as a Novel Therapy for Intractable Epilepsy.Frontiers in cellular neuroscience · 2018Review
- The space where aging acts: focus on the GABAergic synapse.Aging cell · 2017Review
- The Role of Interneurons in Autism and Tourette Syndrome.Trends in neurosciences · 2017Review
- Transplantation of GABAergic interneurons for cell-based therapy.Progress in brain research · 2017Article
- Article
- Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors:Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Due to the inadequacy of endogenous repair mechanisms diseases of the nervous system remain a major challenge to scientists and clinicians. Stem cell based therapy is an exciting and viable strategy that has been shown to ameliorate or even reverse symptoms of CNS dysfunction in preclinical animal models. Of particular importance has been the use of GABAergic interneuron progenitors as a therapeutic strategy. Born in the neurogenic niches of the ventral telencephalon, interneuron progenitors retain their unique capacity to disperse, integrate and induce plasticity in adult host circuitries following transplantation. Here we discuss the potential of interneuron based transplantation strategies as it relates to CNS disease therapeutics. We also discuss mechanisms underlying their therapeutic efficacy and some of the challenges that face the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.