ArticleFrontiers in neural circuits2016
Inhibition by Somatostatin Interneurons in Olfactory Cortex.
Article in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
- Experience-dependent reorganization of inhibitory neuron synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Heterozygous expression of aeLife · 2024Article
- Heterozygous expression of abioRxiv : the preprint server for biology · 2024Article
- Cell-Type-Specific Effects of Somatostatin on Synaptic Transmission in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct organization of two cortico-cortical feedback pathways.Nature communications · 2022Article
- Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- TNF-α Orchestrates Experience-Dependent Plasticity of Excitatory and Inhibitory Synapses in the Anterior Piriform Cortex.Frontiers in neuroscience · 2022Article
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Somatostatin and Astroglial Involvement in the Human Limbic System in Alzheimer's Disease.International journal of molecular sciences · 2021Article
- CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse.ACS chemical neuroscience · 2020Article
- Article
- Somatostatin, Olfaction, and Neurodegeneration.Frontiers in neuroscience · 2020Review
- Prefrontal Disinhibition in Social Fear: A Vital Action of Somatostatin Interneurons.Frontiers in cellular neuroscience · 2020Review
- Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory circuitry plays an integral role in cortical network activity. The development of transgenic mouse lines targeting unique interneuron classes has significantly advanced our understanding of the functional roles of specific inhibitory circuits in neocortical sensory processing. In contrast, considerably less is known about the circuitry and function of interneuron classes in piriform cortex, a paleocortex responsible for olfactory processing. In this study, we sought to utilize transgenic technology to investigate inhibition mediated by somatostatin (SST) interneurons onto pyramidal cells (PCs), parvalbumin (PV) interneurons, and other interneuron classes. As a first step, we characterized the anatomical distributions and intrinsic properties of SST and PV interneurons in four transgenic lines (SST-cre, GIN, PV-cre, and G42) that are commonly interbred to investigate inhibitory connectivity. Surprisingly, the distributions SST and PV cell subtypes targeted in the GIN and G42 lines were sparse in piriform cortex compared to neocortex. Moreover, two-thirds of interneurons recorded in the SST-cre line had electrophysiological properties similar to fast spiking (FS) interneurons rather than regular (RS) or low threshold spiking (LTS) phenotypes. Nonetheless, like neocortex, we find that SST-cells broadly inhibit a number of unidentified interneuron classes including putatively identified PV cells and surprisingly, other SST cells. We also confirm that SST-cells inhibit pyramidal cell dendrites and thus, influence dendritic integration of afferent and recurrent inputs to the piriform cortex. Altogether, our findings suggest that SST interneurons play an important role in regulating both excitation and the global inhibitory network during olfactory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.