ArticleThe Biochemical journal2016
Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.
Open access · greenAbstract read
In one paragraph
Article in The Biochemical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Calcium release deficiency syndrome: an emerging ryanodinopathy.Frontiers in molecular biosciences · 2026Review
- Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans.Circulation · 2025Article
- Cardiac Alternans: From Bedside to Bench and Back.Circulation research · 2023Review
- HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2).International journal of molecular sciences · 2022Article
- Mechanism of carvedilol induced action potential and calcium alternans.Channels (Austin, Tex.) · 2022Article
- Modeling Calcium Cycling in the Heart: Progress, Pitfalls, and Challenges.Biomolecules · 2022Review
- Discordant CaPflugers Archiv : European journal of physiology · 2022Article
- Inhibition of CaPflugers Archiv : European journal of physiology · 2021Article
- Role of Reduced Sarco-Endoplasmic Reticulum CaFrontiers in physiology · 2021Article
- Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling.The Journal of general physiology · 2020Article
- Effect of carvedilol on atrial excitation-contraction coupling, CaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts.JCI insight · 2020Article
- Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia.Computational and mathematical methods in medicine · 2019Article
- The cardiac ryanodine receptor, but not sarcoplasmic reticulum CaThe Journal of biological chemistry · 2018Article
- Disruption of neonatal cardiomyocyte physiology following exposure to bisphenol-a.Scientific reports · 2018Article
- Investigational antiarrhythmic agents: promising drugs in early clinical development.Expert opinion on investigational drugs · 2017Review
- A unified theory of calcium alternans in ventricular myocytes.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Xiaowei ZhongLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Bo SunLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Alexander VallmitjanaDepartment of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08034, Spain.
Tao MiLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Wenting GuoLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Mingke NiLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Ruiwu WangLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
Ang GuoDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
Henry J DuffLibin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Anne M GillisLibin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Long-Sheng SongDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
Leif Hove-MadsenCardiovascular Research Centre, CSIC-ICCC and IIB Sant Pau, Hospital de Sant Pau, Barcelona 08025, Spain.
Raul BenitezDepartment of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08034, Spain.
S R Wayne ChenLibin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.
University of Calgary · CALibin Cardiovascular Institute of Alberta · CAUniversitat Politècnica de Catalunya · ESUniversity of Iowa · USHospital de Sant Pau · ES
Funding
Novel Functions of the E-C Coupling Structural Protein Junctophilin-2 in the HeartR01HL130346 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2016 to 2023
$4.4MT-tubule remodeling and Ca2+-dependent arrhythmogenesis in cardiomyopathies.R01HL090905 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2008 to 2017
$4.0MUnderstanding the multifaceted functions of MG53 in heart failure pathogenesisI01BX002334 · VA · IOWA CITY VA MEDICAL CENTER · PI SONG, LONG-SHENG · 2016 to 2021
–BLRD VA I01 BX002334NHLBI NIH HHS R01 HL090905NHLBI NIH HHS R01 HL130346
Abstract
Beat-to-beat alternations in the amplitude of the cytosolic Ca
Indexed as
AnimalsDisease Models, AnimalElectrocardiographyHeartIsoproterenolMiceMutationMyocardiumMyocytes, CardiacPolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumTachycardiaTachycardia, VentricularIsoproterenolRyanodine Receptor Calcium Release ChannelCa2+ alternansCa2+ release refractorinessryanodine receptorryanodine receptorssarcoplasmic reticulumventricular tachyarrhythmia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.