ArticleThe Journal of urology2017
Risk of Pathological Upgrading and Up Staging among Men with Low Risk Prostate Cancer Varies by Race: Results from the National Cancer Database.
Article in The Journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- A Payment Incentive to Improve Confirmatory Testing in Men With Prostate Cancer.JAMA network open · 2025Article
- The association of patient and disease characteristics with the overtreatment of low-risk prostate cancer from 2010 to 2016.Prostate cancer and prostatic diseases · 2025Article
- Impact of Rectal Spacer on Toxicity Reduction in Men Treated With Proton Versus Photon Therapy.International journal of particle therapy · 2024Article
- Effect of preoperative PI-RADS assessment on pathological outcomes in patients who underwent radical prostatectomy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Genomic Testing in Localized Prostate Cancer Can Identify Subsets of African Americans With Aggressive Disease.Journal of the National Cancer Institute · 2022Article
- Substantial Gleason reclassification in Black men with national comprehensive cancer network low-risk prostate cancer - A propensity score analysis.Prostate cancer and prostatic diseases · 2022Article
- Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy.World journal of urology · 2022Article
- Racial Disparities in Prostate Cancer: Evaluation of Diet, Lifestyle, Family History, and Screening Patterns.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Racial Disparities and Mental Health Effects Within Prostate Cancer.Health psychology research · 2022Article
- The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy.World journal of urology · 2022Article
- Upgrading on radical prostatectomy specimens of very low- and low-risk prostate cancer patients on active surveillance: A population-level analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021Article
- No detrimental effect of a positive family history on postoperative upgrading and upstaging in men with low risk and favourable intermediate-risk prostate cancer: implications for active surveillance.World journal of urology · 2021Article
- African-American men with low-risk prostate cancer treated with radical prostatectomy in an equal-access health care system: implications for active surveillance.Prostate cancer and prostatic diseases · 2020Observational
- Article
- Biparametric MRI prior to Radical Radiation Therapy for Prostate Cancer in a Caribbean Population: Implications for Risk Group Stratification and Treatment.Radiology. Imaging cancer · 2020Article
- Use of multiparametric magnetic resonance imaging and fusion-guided biopsies to properly select and follow African-American men on active surveillance.BJU international · 2019Article
- Clinical significance of the LacdiNAc-glycosylated prostate-specific antigen assay for prostate cancer detection.Cancer science · 2019Observational
- Pathological upgrading and upstaging at radical prostatectomy in Jamaican men with low-risk prostate cancer.Ecancermedicalscience · 2019Article
- Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells.Molecular oncology · 2018Article
- Prostate Cancer Screening Trends After United States Preventative Services Task Force Guidelines in an Underserved Population.Health equity · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThe impact of African-American race on oncologic outcomes for low risk prostate cancer is unclear due to conflicting data. We investigated the effect of African-American race on pathological upgrading and/or up staging at prostatectomy in men with clinically low risk prostate cancer. MATERIALS AND
methodsWe queried the National Cancer Database for men with low risk prostate cancer (clinical stage T2a or less, Gleason score 6 or less, prostate specific antigen less than 10 ng/ml) treated with radical prostatectomy between 2010 and 2013. The outcomes were pathological upgrading to Gleason score greater than 6 (primary) or Gleason score greater than 3+4=7 (secondary) and/or up staging (pathological T3-4 or N1 disease). The association between race and the end points was assessed using multivariable logistic regression. To further adjust for potential confounders, stratification by urban residence and comorbidity score, and subgroup analyses were performed.
resultsWith adjustment for age, comorbidity, income, urban residence, T stage, prostate specific antigen and percentage of positive biopsy cores, African-American race conferred 1.2-fold higher odds of pathological upgrading to Gleason score greater than 6 and/or up staging (OR 1.2, 95% CI 1.1-1.3, p <0.01). African-American race also was an independent predictor of pathological upgrading to Gleason score greater than 3+4=7 and/or up staging (p=0.03).
conclusionsAfrican-American men with low risk prostate cancer are more likely to harbor higher risk disease, which may lead to adverse outcomes. This finding alone does not preclude active surveillance. However, race should be considered as men weigh the risks and benefits of active surveillance vs treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.