ArticleBMC evolutionary biology2016
The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- An acidic residue within the OCT4 dimerization interface of SOX17 is necessary and sufficient to overcome its pluripotency-inducing activity.Stem cell reports · 2025Article
- Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos.eLife · 2025Article
- The emergence of Sox and POU transcription factors predates the origins of animal stem cells.Nature communications · 2024Article
- NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl.PLoS biology · 2023Article
- The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.International journal of molecular sciences · 2023Review
- Molecular Evolution and Inheritance Pattern ofGenes · 2022Article
- Article
- Yamanaka Factors in the Budding TunicateFrontiers in cell and developmental biology · 2022Article
- Key features of the POU transcription factor Oct4 from an evolutionary perspective.Cellular and molecular life sciences : CMLS · 2021Review
- The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.Stem cell reviews and reports · 2021Article
- The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells.Stem cell reports · 2021Article
- SOX Transcription Factors as Important Regulators of Neuronal and Glial Differentiation During Nervous System Development and Adult Neurogenesis.Frontiers in molecular neuroscience · 2021Review
- Distinct transcriptional programs of SOX2 in different types of small cell lung cancers.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons.International journal of molecular sciences · 2019Review
- Testing the role of SOX15 in human primordial germ cell fate.Wellcome open research · 2019Article
- Duplication and expression of Sox genes in spiders.BMC evolutionary biology · 2018Article
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network.Journal of animal science and biotechnology · 2018Article
- Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundIn mouse ES cells, the function of Sox2 is essential for the maintenance of pluripotency. Since the Sox-family of transcription factors are well conserved in the animal kingdom, addressing the evolutionary origin of Sox2 function in pluripotent stem cells is intriguing from the perspective of understanding the origin of pluripotency.
resultsHere we approach this question using a functional complementation assay in inducible Sox2-null ES cells. Assaying mouse Sox proteins from different Groups, we found that only Group B1 and Group G proteins were able to support pluripotency. Interestingly, invertebrate homologs of mammalian Group B1 Sox proteins were able to replace the pluripotency-associated function of mouse Sox2. Moreover, the mouse ES cells rescued by the Drosophila SoxNeuro protein are able to contribute to chimeric embryos.
conclusionsThese data indicate that the function of mouse Sox2 supporting pluripotency is based on an evolutionally conserved activity of the Group B1 Sox family. Since pluripotent stem cell population in developmental process could be regarded as the evolutional novelty in vertebrates, it could be regarded as a co-optional use of their evolutionally conserved function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.