Trial reportJournal of neurophysiology2016
Progressive resistance exercise restores some properties of the triphasic EMG pattern and improves bradykinesia: the PRET-PD randomized clinical trial.
Trial report in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With Meta-Analyses.Neurorehabilitation and neural repair · 2023Pooled it
- Efficacy and evaluation of therapeutic exercises on adults with Parkinson's disease: a systematic review and network meta-analysis.BMC geriatrics · 2022Pooled it
- Physical Therapist Management of Parkinson Disease: A Clinical Practice Guideline From the American Physical Therapy Association.Physical therapy · 2022Guideline
- Trial
- Progressive Resistance Training Improves Bradykinesia, Motor Symptoms and Functional Performance in Patients with Parkinson's Disease.Clinical interventions in aging · 2020Trial
- Cross-sectional comparison of lower-limb muscle strength and contractile properties according to Parkinson's disease and sarcopenia status.Frontiers in medicine · 2026Article
- Motor segmentation: a key neuromuscular impairment in people with parkinson's disease.Experimental brain research · 2025Article
- Comparison of Various Smoothness Metrics for Upper Limb Movements in Middle-Aged Healthy Subjects.Sensors (Basel, Switzerland) · 2023Article
- Measures of motor segmentation from rapid isometric force pulses are reliable and differentiate Parkinson's disease from age-related slowing.Experimental brain research · 2022Article
- Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy.Neurorehabilitation and neural repair · 2021Review
- A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Evidence for Early and Regular Physical Therapy and Exercise in Parkinson's Disease.Seminars in neurology · 2021Review
- Autonomic Function in Patients With Parkinson's Disease: From Rest to Exercise.Frontiers in physiology · 2021Review
- Evolving concepts on bradykinesia.Brain : a journal of neurology · 2020Review
- Rationale and Design of the PAIRED Trial: Partnered Dance Aerobic Exercise as a Neuroprotective, Motor, and Cognitive Intervention in Parkinson's Disease.Frontiers in neurology · 2020Article
- Altered cardiorespiratory regulation during exercise in patients with Parkinson's disease: A challenging non-motor feature.SAGE open medicine · 2020Review
- Antagonist muscle activity during reactive balance responses is elevated in Parkinson's disease and in balance impairment.PloS one · 2019Observational
- A 12-Week Cycling Training Regimen Improves Upper Limb Functions in People With Parkinson's Disease.Frontiers in human neuroscience · 2018Article
- Levodopa-Induced Changes in Electromyographic Patterns in Patients with Advanced Parkinson's Disease.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
In Parkinson's disease (PD), the characteristic triphasic agonist and antagonist muscle activation pattern during ballistic movement is impaired: the number of agonist muscle bursts is increased, and the amplitudes of the agonist and antagonist bursts are reduced. The breakdown of the triphasic electromyographic (EMG) pattern has been hypothesized to underlie bradykinesia in PD. Progressive resistance exercise has been shown to improve clinical measures of bradykinesia, but it is not clear whether the benefits for bradykinesia are accompanied by changes in agonist and antagonist muscle activity. This study examined the spatiotemporal changes in agonist and antagonist muscle activity following 24 mo of progressive resistance exercise and the combined relationship between spatiotemporal muscle activity and strength measures and upper limb bradykinesia. We compared the effects of progressive resistance exercise training (PRET) with a nonprogressive exercise intervention, modified Fitness Counts (mFC), in patients with PD. We randomized 48 participants with mild-to-moderate PD to mFC or PRET. At the study endpoint of 24 mo, participants randomized to PRET compared with mFC had significantly faster movement velocity, accompanied by significant increases in the duration, magnitude, and magnitude normalized to duration of the 1st agonist burst and fewer number of agonist bursts before peak velocity. The antagonist muscle activity was increased relative to baseline but did not differ between groups. Spatiotemporal EMG muscle activity and muscle strength were significantly associated with upper limb bradykinesia. These findings demonstrate that progressive resistance exercise improves upper limb movement velocity and restores some aspects of the triphasic EMG pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.