ArticleAmerican journal of physiology. Renal physiology2016
Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.
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Article in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Acid-sensing ion channel 2a assembles with epithelial NaThe Journal of biological chemistry · 2026Article
- Germline targeted next-generation sequencing in patients with adrenal incidentalomas.Frontiers in endocrinology · 2025Article
- Influence of proteolytic cleavage of ENaC's γ subunit upon NaAmerican journal of physiology. Renal physiology · 2024Article
- Epithelial NaComprehensive Physiology · 2024Review
- Mice lacking γENaC palmitoylation sites maintain benzamil-sensitive Na+ transport despite reduced channel activity.JCI insight · 2023Article
- Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology inMembranes · 2023Article
- The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023Review
- Kidney ion handling genes and their interaction in blood pressure control.Bioscience reports · 2022Review
- Rare Variants in Genes Encoding Subunits of the Epithelial NaHypertension (Dallas, Tex. : 1979) · 2022Article
- Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.Pflugers Archiv : European journal of physiology · 2022Review
- Accessibility of ENaC extracellular domain central core residues.The Journal of biological chemistry · 2022Article
- Study design, general characteristics of participants, and preliminary findings from the metabolome, microbiome, and dietary salt intervention study (MetaSalt).Chronic diseases and translational medicine · 2021Article
- Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression.American journal of physiology. Renal physiology · 2021Article
- Epithelial Sodium Channel and Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Regulating ENaC's gate.American journal of physiology. Cell physiology · 2020Review
- Analyses of epithelial NaThe Journal of biological chemistry · 2019Article
- Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.American journal of physiology. Renal physiology · 2019Article
- New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature.Current opinion in nephrology and hypertension · 2019Review
- Conserved cysteines in the finger domain of the epithelial NaThe Journal of biological chemistry · 2018Article
- Epithelial NaAnnual review of physiology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Evan C RayRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jingxin ChenRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Tanika N KellyDepartment of Epidemiology, Tulane University, New Orleans, Louisiana.
Jiang HeDepartment of Epidemiology, Tulane University, New Orleans, Louisiana.
L Lee HammDepartment of Medicine, Tulane University, New Orleans, Louisiana.
Dongfeng GuState Key Laboratory of Cardiovascular Disease, Division of Population Genetics, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lawrence C ShimminHuman Genetics Center, University of Texas School of Public Health, Houston, Texas.
James E HixsonHuman Genetics Center, University of Texas School of Public Health, Houston, Texas.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri.
Shaohu ShengRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; shaohu@pitt.edu.ORCID 0000-0002-7198-1702
Thomas R KleymanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
University of Pittsburgh · USTulane University · USThe University of Texas Health Science Center at Houston · USChinese Academy of Medical Sciences & Peking Union Medical College · CNWashington University in St. Louis · US
Funding
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4MGenetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6MBiomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2MRenal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1MFamily-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8MSodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8MProteolytic activation of ENaC in Proteinuric Kidney DiseaseK08DK110332 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, EVAN CROSS · 2016 to 2021
$903kNHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS U01 HL072507NIDDK NIH HHS K08 DK110332NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R37 DK051391NIDDK NIH HHS T32 DK061296
Abstract
Mutations in genes encoding subunits of the epithelial Na
Indexed as
Mutation, MissenseAllelesAnimalsBlood PressureEpithelial Sodium ChannelsGene FrequencyGenetic VariationHumansHypertensionOocytesSodium, DietaryXenopus laevisEpithelial Sodium ChannelsSodium, Dietaryepithelial sodium channelGenetic Epidemiology Network of Salt Sensitivitysalt-sensitive hypertensionsodium self-inhibitiontwo-electrode voltage clamp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.