Evidence map›Paper›PMID 27582096›Full record

ArticleAmerican journal of physiology. Renal physiology2016

Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.

Jermaine G Johnston, Joshua S Speed, Chunhua Jin, David M Pollock

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 48 citations in OpenAlex.

  1. Endothelin antagonists for hypertension: has their time finally arrived?Clinical science (London, England : 1979) · 2025
    Review
  2. Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025
    Review
  3. Article
  4. Article
  5. Sex-Specific Differences in Kidney Function and Blood Pressure Regulation.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jermaine G JohnstonCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Joshua S SpeedCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Chunhua JinCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David M PollockCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama dpollock@uab.edu.
University of Alabama at Birmingham · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI HARSHFIELD, GREGORY ALAN · 2002 to 2018
$31.1M
Renal endothelin receptor-specific function in angiotensin ll-dependent hypertensP01HL095499 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2010 to 2014
$11.1M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Endothelin - Mechanisms in Hypertension and ObesityK99HL127178 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SPEED, JOSHUA S · 2016 to 2017
$308k
NHLBI NIH HHS K99 HL127178NHLBI NIH HHS P01 HL069999NHLBI NIH HHS P01 HL095499NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Recent studies suggested a direct link between circadian rhythms and regulation of sodium excretion. Endothelin-1 (ET-1) regulates sodium balance by promoting natriuresis through the endothelin B receptor (ET

Indexed as

AnimalsAtrasentanEndothelin-1Endothelin Receptor AntagonistsFemaleMaleNatriuresisPyrrolidinesRatsRats, Inbred WKYRats, TransgenicReceptor, Endothelin BSex FactorsSodiumTime FactorsAtrasentanEndothelin-1Endothelin Receptor AntagonistsPyrrolidinesReceptor, Endothelin BSodiumcircadian rhythmETA receptorsETB receptorskidneymale and femalerats

Identifiers

PMID27582096
PMCPMC5130462
OpenAlexW2517399874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.