Evidence map›Paper›PMID 27581950›Full record

ArticleScientific reports2016

Longitudinal in vivo MRI in a Huntington's disease mouse model: Global atrophy in the absence of white matter microstructural damage.

Jessica J Steventon, Rebecca C Trueman, Da Ma, Emma Yhnell, Zubeyde Bayram-Weston, Marc Modat, Jorge Cardoso, Sebastian Ourselin, Mark Lythgoe, Andrew Stewart and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

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  18. Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jessica J SteventonCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
Rebecca C TruemanBrain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Da MaCentre for Medical Imaging Computing, University College London, London, UK.
Emma YhnellBrain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Zubeyde Bayram-WestonBrain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Marc ModatCentre for Medical Imaging Computing, University College London, London, UK.
Jorge CardosoCentre for Medical Imaging Computing, University College London, London, UK.
Sebastian OurselinCentre for Medical Imaging Computing, University College London, London, UK.
Mark LythgoeCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Andrew StewartExperimental MRI Centre, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Anne E RosserBrain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Derek K JonesCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
Cardiff University · GBUniversity College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Huntington's disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal magnetic resonance imaging (MRI) allows for disease progression to be probed non-invasively. In the HdhQ150 mouse model of HD, in vivo MRI was employed at two time points, before and after the onset of motor signs, to assess brain macrostructure and white matter microstructure. Ex vivo MRI, immunohistochemistry, transmission electron microscopy and behavioural testing were also conducted. Global brain atrophy was found in HdhQ150 mice at both time points, with no neuropathological progression across time and a selective sparing of the cerebellum. In contrast, no white matter abnormalities were detected from the MRI images or electron microscopy images alike. The relationship between motor function and MR-based structural measurements was different for the HdhQ150 and wild-type mice, although there was no relationship between motor deficits and histopathology. Widespread neuropathology prior to symptom onset is consistent with patient studies, whereas the absence of white matter abnormalities conflicts with patient data. The myriad reasons for this inconsistency require further attention to improve the translatability from mouse models of disease.

Indexed as

AnimalsAtrophyBody WeightBrainBrain MappingDisease Models, AnimalDisease ProgressionGene ExpressionHumansHuntingtin ProteinHuntington DiseaseLongitudinal StudiesMagnetic Resonance ImagingMaleMiceMice, TransgenicHtt protein, mouseHuntingtin ProteinNerve Tissue ProteinsNuclear Proteins

Identifiers

PMID27581950
PMCPMC5007531
OpenAlexW2509688377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.