ArticleScientific reports2016
Visualization of in vivo metabolic flows reveals accelerated utilization of glucose and lactate in penumbra of ischemic heart.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Progress in monitoring molecular, cellular and metabolic dynamics using mass spectrometry imaging.Bioanalysis · 2025Review
- Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles.NPJ cardiovascular health · 2025Review
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- Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation.iScience · 2024Article
- Mass spectrometry in animal health laboratories: recent history, current applications, and future directions.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Review
- Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.Science (New York, N.Y.) · 2024Article
- Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19.Nature communications · 2023Article
- Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation.Nature metabolism · 2023Article
- Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation.Research square · 2023Article
- Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem.Nature communications · 2023Article
- Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics.International journal of molecular sciences · 2022Article
- Analyzing cell-type-specific dynamics of metabolism in kidney repair.Nature metabolism · 2022Article
- Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis.Journal of proteome research · 2022Review
- TraVis Pies: A Guide for Stable Isotope Metabolomics Interpretation Using an Intuitive Visualization.Metabolites · 2022Article
- Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism.Nature communications · 2022Article
- Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice.The Journal of experimental medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute ischemia produces dynamic changes in labile metabolites. To capture snapshots of such acute metabolic changes, we utilized focused microwave treatment to fix metabolic flow in vivo in hearts of mice 10 min after ligation of the left anterior descending artery. The left ventricle was subdivided into short-axis serial slices and the metabolites were analyzed by capillary electrophoresis mass spectrometry and matrix-assisted laser desorption/ionization imaging mass spectrometry. These techniques allowed us to determine the fate of exogenously administered (13)C6-glucose and (13)C3-lactate. The penumbra regions, which are adjacent to the ischemic core, exhibited the greatest adenine nucleotide energy charge and an adenosine overflow extending from the ischemic core, which can cause ischemic hyperemia. Imaging analysis of metabolic pathway flows revealed that the penumbra executes accelerated glucose oxidation, with remaining lactate utilization for tricarboxylic acid cycle for energy compensation, suggesting unexpected metabolic interplays of the penumbra with the ischemic core and normoxic regions.
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