ArticleProceedings. Biological sciences2016
Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Self-assembling T7 phage syringes with modular genomes for targeted delivery of penicillin against β-lactam-resistant Escherichia coli.BMC biotechnology · 2025Article
- Taking cues from ecological and evolutionary theories to expand the landscape of disgust.Proceedings. Biological sciences · 2024Review
- Mini review advantages and limitations of lytic phages compared with chemical antibiotics to combat bacterial infections.Heliyon · 2024Review
- Conditions for the spread of CRISPR-Cas immune systems into bacterial populations.The ISME journal · 2024Article
- Antibiotic Resistance: Do We Need Only Cutting-Edge Methods, or Can New Visions Such as One Health Be More Useful for Learning from Nature?Antibiotics (Basel, Switzerland) · 2023Review
- Article
- Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.Proceedings. Biological sciences · 2021Article
- The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa.The ISME journal · 2021Article
- It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Article
- The ecology and evolution of microbial CRISPR-Cas adaptive immune systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Genome-wide correlation analysis suggests different roles of CRISPR-Cas systems in the acquisition of antibiotic resistance genes in diverse species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Article
- Phage Therapy Faces Evolutionary Challenges.Viruses · 2018Article
- Article
- Immune loss as a driver of coexistence during host-phage coevolution.The ISME journal · 2018Article
- Mechanisms and consequences of diversity-generating immune strategies.Nature reviews. Immunology · 2017Review
- Non-classical phase diagram for virus bacterial coevolution mediated by clustered regularly interspaced short palindromic repeats.Journal of the Royal Society, Interface · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Migration of hosts and parasites can have a profound impact on host-parasite ecological and evolutionary interactions. Using the bacterium Pseudomonas aeruginosa UCBPP-PA14 and its phage DMS3vir, we here show that immigration of naive hosts into coevolving populations of hosts and parasites can influence the mechanistic basis underlying host defence evolution. Specifically, we found that at high levels of bacterial immigration, bacteria switched from clustered regularly interspaced short palindromic repeats (CRISPR-Cas) to surface modification-mediated defence. This effect emerges from an increase in the force of infection, which tips the balance from CRISPR to surface modification-based defence owing to the induced and fixed fitness costs associated with these mechanisms, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.