ReviewEuropean respiratory review : an official journal of the European Respiratory Society2016
Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing.
Review in European respiratory review : an official journal of the European Respiratory Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
- Trial
- The fully engaged inspiratory muscle training reduces postoperative pulmonary complications rate and increased respiratory muscle function in patients with upper abdominal surgery: a randomized controlled trial.Annals of medicine · 2022Trial
- The effect of long-acting dual bronchodilator therapy on exercise tolerance, dynamic hyperinflation, and dead space during constant work rate exercise in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- The modified Borg cycle strength test (mBCST): Feasibility and physiological response in people with COPD and healthy older adults.Experimental physiology · 2026Article
- Mechanisms of exercise limitation and prevalence of pulmonary hypertension in hypersensitivity pneumonitis.ERJ open research · 2026Article
- Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China.BMJ open respiratory research · 2024Article
- Identifying limitations to exercise with incremental cardiopulmonary exercise testing: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Comparable Ventilatory Inefficiency at Maximal and Submaximal Performance in COPD vs. CHF subjects: An Innovative Approach.Arquivos brasileiros de cardiologia · 2024Article
- Cardiopulmonary exercise testing criteria for advanced therapies in patients with heart failure.Heart failure reviews · 2023Review
- Effect of maximum exercise on left ventricular deformation and its correlation with cardiopulmonary exercise capacity in competitive athletes.Echo research and practice · 2023Article
- Laboratory and free-living gait performance in adults with COPD and healthy controls.ERJ open research · 2023Article
- Reference equations for breathlessness during incremental cycle exercise testing.ERJ open research · 2023Article
- Responses to incremental exercise and the impact of the coexistence of HF and COPD on exercise capacity: a follow-up study.Scientific reports · 2022Article
- Practical guide to cardiopulmonary exercise testing in adults.Respiratory research · 2022Review
- Value of Cardiopulmonary Exercise Testing in the Prognosis Assessment of Chronic Obstructive Pulmonary Disease Patients: A Retrospective, Multicentre Cohort Study.Respiration; international review of thoracic diseases · 2022Article
- Different Responses to Pulmonary Rehabilitation in COPD Patients with Different Work Efficiencies.International journal of chronic obstructive pulmonary disease · 2022Article
- Exertional ventilation/carbon dioxide output relationship in COPD: from physiological mechanisms to clinical applications.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Ventilatory inefficiency: a key physiopathological mechanism increasing dyspnea and reducing exercise capacity in chronic obstructive pulmonary disease.Journal of thoracic disease · 2021Article
- Pulmonary function testing in COPD: looking beyond the curtain of FEV1.NPJ primary care respiratory medicine · 2021Review
- Multidimensional breathlessness assessment during cardiopulmonary exercise testing in healthy adults.European journal of applied physiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity-related dyspnoea is often the most distressing symptom experienced by patients with chronic obstructive pulmonary disease (COPD) and can persist despite comprehensive medical management. It is now clear that dyspnoea during physical activity occurs across the spectrum of disease severity, even in those with mild airway obstruction. Our understanding of the nature and source of dyspnoea is incomplete, but current aetiological concepts emphasise the importance of increased central neural drive to breathe in the setting of a reduced ability of the respiratory system to appropriately respond. Since dyspnoea is provoked or aggravated by physical activity, its concurrent measurement during standardised laboratory exercise testing is clearly important. Combining measurement of perceptual and physiological responses during exercise can provide valuable insights into symptom severity and its pathophysiological underpinnings. This review summarises the abnormal physiological responses to exercise in COPD, as these form the basis for modern constructs of the neurobiology of exertional dyspnoea. The main objectives are: 1) to examine the role of cardiopulmonary exercise testing (CPET) in uncovering the physiological mechanisms of exertional dyspnoea in patients with mild-to-moderate COPD; 2) to examine the escalating negative sensory consequences of progressive respiratory impairment with disease advancement; and 3) to build a physiological rationale for individualised treatment optimisation based on CPET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.