ReviewEuropean respiratory review : an official journal of the European Respiratory Society2016
Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors.
Review in European respiratory review : an official journal of the European Respiratory Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Oxygen use in chronic heart failure to relieve breathlessness: A systematic review.Heart failure reviews · 2020Pooled it
- Trial
- Beyond Breathlessness Intensity: A Prospective Psychometric Validation of the Multidimensional Dyspnea Profile in Heart Failure with Reduced and Mildly Reduced Ejection Fraction.Journal of clinical medicine · 2026Article
- Resting and Exercise Lactate Dynamics in Heart Failure: Guiding Therapeutic Optimization.Biomedicines · 2026Review
- COPD-Asthma-Heart Failure Overlap: Optimizing Bronchodilators and ICS in a High-Risk Triad.Journal of asthma and allergy · 2026Review
- Inspiratory muscle weakness further impairs exercise capacity and respiratory functions and increases dyspnea perception in patients with heart failure.Scientific reports · 2025Article
- Observational
- Core and bridging symptoms in patients with atrial fibrillation: a network analysis.Frontiers in cardiovascular medicine · 2025Article
- Cardiopulmonary and hemodynamic responses toFrontiers in physiology · 2025Article
- Impact of Exercise on Physiological, Biochemical, and Analytical Parameters in Patients with Heart Failure with Reduced Ejection Fraction.Medicina (Kaunas, Lithuania) · 2024Review
- Prognostic Influence of Lung Compliance in Patients with Cardiogenic Shock and Invasive Mechanical Ventilation.Reviews in cardiovascular medicine · 2024Article
- The 30-second chair stand test (CS30) as a predictor of exercise tolerance in elderly individuals (≥75 years) with stage A/B heart failure.International journal of cardiology. Heart & vasculature · 2024Article
- Beyond Medical Therapy-An Update on Heart Failure Devices.Journal of cardiovascular development and disease · 2024Review
- Physical Fitness Is Directly Related to Exercise Capacity and Ventilatory Response to Exercise in Men with HFrEF.Journal of clinical medicine · 2024Article
- Better Respiratory Function in Heart Failure Patients With Use of Central-Acting Therapeutics.CJC open · 2024Article
- Impact of Different Exercise Modalities on Physical Function and Quality of Life in Patients with Heart Failure.Journal of multidisciplinary healthcare · 2024Review
- Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case-control study.Frontiers in physiology · 2024Article
- Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction.Experimental physiology · 2023Review
- Risk Stratification in Transthyretin Cardiac Amyloidosis: The Added Value of Lung Spirometry.Journal of clinical medicine · 2023Article
- Clinical determinants and prognostic significance of hypocapnia in acute heart failure.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exertional dyspnoea is among the dominant symptoms in patients with chronic heart failure and progresses relentlessly as the disease advances, leading to reduced ability to function and engage in activities of daily living. Effective management of this disabling symptom awaits a better understanding of its underlying physiology.Cardiovascular factors are believed to play a major role in dyspnoea in heart failure patients. However, despite pharmacological interventions, such as vasodilators or inotropes that improve central haemodynamics, patients with heart failure still complain of exertional dyspnoea. Clearly, dyspnoea is not determined by cardiac factors alone, but likely depends on complex, integrated cardio-pulmonary interactions.A growing body of evidence suggests that excessively increased ventilatory demand and abnormal "restrictive" constraints on tidal volume expansion with development of critical mechanical limitation of ventilation, contribute to exertional dyspnoea in heart failure. This article will offer new insights into the pathophysiological mechanisms of exertional dyspnoea in patients with chronic heart failure by exploring the potential role of the various constituents of the physiological response to exercise and particularly the role of abnormal ventilatory and respiratory mechanics responses to exercise in the perception of dyspnoea in patients with heart failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.